The invention discloses a coal mining method of a full-negative-pressure continuous mining machine for leftover coal, and belongs to the technical field of coal mining. The problems that when a coal mining method of a continuous mining machine is adopted in leftover coal resources, full-negative-pressure ventilation cannot be achieved in a mining cave, and the yield is low are solved. The method comprises the four steps of crossheading roadway arrangement, stoping unit branch roadway arrangement, stoping unit mining and leftover coal section mining. According to the method, roadway arrangement is flexible, the resource recovery rate is high, local ventilator air supply is completely canceled during mining cave stoping, ventilation air methane air flow is prevented from returning to a stoping branch roadway, branch roadway through holes are additionally formed in a stoping unit, and ventilation management and safety are facilitated; and meanwhile, according to the coal mining method, one continuous mining machine and matched equipment are adopted for roadway tunneling and mining cave stoping, mining and tunneling are integrated, the number of newly-added personnel is small, the investment is relatively low, the coal yield is guaranteed, and good benefits can be obtained.