The invention provides a multi-pulse-set optimization design method of a space-based early warning radar, and belongs to the technical field of radar early warning. Various factors including target doppler ambiguity, range clutter ambiguity, range blind areas, space filling time, target range ambiguity resolving and speed ambiguity resolving are fully considered, while reliable target detection isensured, the influence of transmission pulse shielding and sub-satellite point shielding is lowered to the maximum extent, and therefore range ambiguity clutters and range detection blind areas are reduced. Specifically, through the design criteria of the minimum multi-pulse, while reliable target detection is ensured, the influence of transmission pulse shielding and sub-satellite point shielding is lowered to the maximum extent, and therefore the range ambiguity clutters and the range detection blind areas are reduced. The relation between a multi-pulse set and the duty ratio and the protecting window length is restrained, no space and time filling is required during switching of different multi-pulses of the space-based radar, and working efficiency of the radar is greatly improved.