The invention discloses a spatial-domain filtering-based CBCT panoramic image sharpening method, which includes the following steps: firstly, an image is read, moreover, a Gaussian low-pass filter, the radius of which is R and the standard deviation of which is Sigma, is used for carrying out convolution on the image, so that a smooth image is obtained, blurred images are then removed from the original image, so that a template is generated, and finally, a weighted part of the template is added on the original image. The contrast of the CBCT image is increased by the method, particularly, the soft tissue parts in the CBCT image are effectively enhanced, moreover, the algorithm is simple, the computing speed is high, a satisfactory result can be obtained by adjusting two parameters, and thereby effective help is offered to clinical applications for doctors.