The invention relates to a large transport vehicle safety protection system and an early warning method. The early warning method comprises the steps that S1, the system conducts power-on self-test; S2, a millimeter wave radar assembly transmits obstacle target information detected in real time to a system processing terminal, and a camera assembly transmits road image information recorded in realtime to the system processing terminal; S3, the system processing terminal gives a radar confidence factor and a camera confidence factor to each target in real time; S4, the total confidence of eachtarget is calculated in real time, and whether the target is a real target or not is judged in real time according to the total confidence; and S5, according to the current vehicle speed and the realtarget, early warning is carried out on a right ahead target during starting, or a right ahead target during driving, or a side target during steering, or a side target during lane changing, or a rear target during lane changing. According to the invention, radar, camera and vehicle driving parameter information are combined, the detection range is expanded, and the method is used for vehicle front dead zone detection, lateral anti-collision and rear dead zone detection.