The RO installation for producing ultrapure water, preferably for medicinal flushing solutions, with a raw water supply conduit, which leads to a feed tank, from which a conduit with a pump leads to the primary side of an RO membrane, from where a concentrate circulation conduit leads back to the feed tank, and with a permeate feed conduit and a first permeate circulation conduit, which either extends to a permeate return conduit, which leads to the feed tank, or communicates via a further permeate circulation conduit with the secondary side of the RO membrane, and with a filtrate outlet conduit is characterized in that the primary circuit including the feed tank, the conduit, the primary side of the RO membrane and the concentrate circulation conduit and the secondary circuit including the secondary side of the RO membrane, the first permeate circulation conduit and the further permeate circulation conduit may be flowed through by a disinfecting and cleaning agent independently of one another, wherein a disinfecting agent conduit connected to a disinfecting agent container communicates with the first permeate circulation conduit and the disinfecting agent conduit is provided with a disinfecting agent pump and that the permeate return conduit includes a pressure holding valve with a bypass valve.