The invention relates to a modular large wall board, and a manufacturing method and application thereof, belonging to the field of building materials. The board is mainly used for walls of buildings like workshops, storehouses and hangars. The board comprises a hoisting hole, a window frame, surface layers, a heat-insulation layer, and first to fourth edgings, wherein the first and second edgings are located at the left and right ends of the board respectively and are male and female structures which can be assembled respectively; the third and fourth edgings are located at the upper and lower ends of the board respectively; the hoisting hole is located in the first and second edgings and transversely passes through the whole board; and the heat-insulation layer is prepared from biological straw, cement and cotton felt, the biological straw and the cement are integrally arranged to form straw cement, and the cotton felt are adhered on two sides of the straw cement. The board provided by the invention has the advantages of great strength, light weight, heat insulation performance, noise-reducing performance, low cost and capacity of reducing environmental pollution.