The invention discloses a novel full-automatic hot melt adhesive carton sealing machine. The novel full-automatic hot melt adhesive carton sealing machine structurally comprises an automatic cover folding device, a width adjustable left conveying device, a bottom glue pressing mechanism, a carton positioning device, a top adhesive tape barrel mechanism, a height adjusting handle, a lifting frame,a conveying roller, a machine body, a width adjustable right conveying device, an adhesive tape fixing roller, supporting feet, universal wheels, a height adjustable supporting frame and a containingtable. The novel full-automatic hot melt adhesive carton sealing machine has the beneficial effects that the full-automatic carton sealing machine can automatically fold carton folding covers before carton sealing, folding of the left-right folding covers is conducted firstly, then folding of the front-back folding covers is conducted, manual folding is not needed, the labor intensity of workers is relieved, manpower is saved, and the work efficiency is improved; meanwhile, a sealed carton can be uniform and attractive, the quality of the folding covers of the carton can be guaranteed, the modern assembly line operation requirement can be met, and using is safe, stable, convenient and reliable.