The invention discloses a pipeline pressure pulsation energy collecting device with a supercharging device, and belongs to the technical field of hydroelectric generation and low-power-consumption newenergy. The device is composed of a pressurizing pipeline, a main pipeline, a base, a top cover, a plastic film, a piezoelectric stack, a mechanical amplifier, a piezoelectric frame and a sealing rubber ring. The pressurizing pipeline is connected with the main pipeline through threads, the sealing rubber ring is installed between the pressurizing pipeline and the main pipeline, the piezoelectricstack is pasted on the piezoelectric frame and is connected with the mechanical amplifier through pasting, and the mechanical amplifier is fixed above the main pipeline through a stud. When water flow passes through the pressurizing pipeline, the pressure pulsation of the pipeline is increased and transmitted to the plastic film to generate vibration, and the vibration is transmitted to the piezoelectric stack after passing through the mechanical amplifier, so that the piezoelectric stack deforms to generate electric energy. Since pipeline pressure pulsation is increased, the vibration amplitude generated by the pressure pulsation is amplified and the energy collection efficiency is improved, and the device is simple in structure, low in cost and easy to popularize.