44 results about "Small brainstem" patented technology

An implantable hearing unit is provided that includes an implantable microphone, a rechargeable power storage device and a speech signal processor. The hearing unit further includes a signal coupling device that is adapted for electrical interconnection to an implantable auditory stimulation device, which is operative to stimulate an auditory component of a patient. Such a stimulation device may include cochlear implants, brain stem stimulation systems, auditory nerve stimulation systems, and middle or inner ear transducer systems. The signal coupling device is operative to provide processed drive signals from the signal processor to the stimulation device as well provide power from the power storage device to operate the stimulation device. In one arrangement, the signal coupling device is a wireless coupling between first and second coils. In such an arrangement, the hearing unit may be utilized with an existing implanted stimulation device to make that device a fully implanted hearing system.

According to one embodiment, a neurological stimulation system is adapted for implantation into a person's body for electrical, chemical, or combined electrical and chemical stimulation of target nerve tissue in the person's brain stem. For electrical stimulation, the system includes an electrical stimulation lead adapted for implantation on, in, or near the brain stem, and including electrodes adapted to be positioned on, in, or near target nerve tissue in the brain stem, for delivering electrical stimulation energy to the target nerve tissue. For chemical stimulation, the system includes an infusion catheter adapted for implantation on, in, or near the brain stem, and including openings adapted to be positioned on, in, or near target nerve tissue in the brain stem, for delivering a chemical to the target nerve tissue. The system also includes a stimulation source adapted for implantation in the person's body and operable to generate pulses of electrical stimulation energy or pulses of the chemical, for delivery to the target nerve tissue in the brain stem.

Means is provided for generating a vibration or a vibration signal, which contains audible range components that are vibration components in the audible frequency range and super-highfrequency components within a range exceeding the audible frequency range up to a predetermined maximum frequency, and which has an autocorrelation order represented by at least either one of a first property and a second property. By applying the vibration or an actual vibration generated from the vibration signal to a human being, a fundamental brain activation effect for activating the fundamental brain network system constituted of a fundamental brain including the brain stem, thalamus and hypothalamus that are regions to bear the fundamental function of the human being and the fundamental brain network of neuronal projection from the fundamental brain to various brain regions is introduced.

A method for increasing cerebral blood flow in a patient. A electrical stimulating device is provided. The electrical stimulating device is applied to the patient at a region adjacent the cervical sympathetic chain, the brain stem, the head, or the sympathetic nervous system. The electrical stimulating device is applied by any route selected from transcutaneous, subcutaneous, and subarachnoid. The electrical stimulating device is activated to stimulate or inhibit nerve impulses of the cervical sympathetic chain, thereby producing vasodilation in the cerebral vasculature, thereby increasing cerebral blood flow. Devices for increasing cerebral blood flow in a patient are also described.

A method and device for automatically assessing loss of hearing sensitivity and compression (recruitment) with user defined frequency resolution by means of extrapolated DPOAE I / O functions and ABRs as well as for automatically fitting hearing aids without any cooperation of the subject tested using a device having a display screen attached to a handheld device generating and collecting otoacoustic emission signals and brain stem response signals into a programmed with a clinical audiogram with fitting parameters for hearing aids calculated on the basis of assessed hearing threshold and compression and identifying the type of hearing required for the individual.

An apparatus consistent with the present invention comprises a sensor for receiving a signal representing eye tremor and a processor for monitoring eye tremor while receiving the signal. A method consistent with the present invention includes receiving a signal representing eye tremor, comparing the received signal representing eye tremor to at least one reference value, and classifying a patient's brain stem function using the comparison of the received signal representing eye tremor to at least one reference value. An embodiment consistent with the present invention includes an ocular micro tremor (OMT) sensor and associated signal processing hardware and software for clinical analyses.

A method and device for automatically assessing loss of hearing sensitivity and compression (recruitment) with user defined frequency resolution by means of extrapolated DPOAE I / O functions and ABRs as well as for automatically fitting hearing aids without any cooperation of the subject tested using a device having a display screen attached to a handheld device generating and collecting otoacoustic emission signals and brain stem response signals into a programmed with a clinical audiogram with fitting parameters for hearing aids calculated on the basis of assessed hearing threshold and compression and identifying the type of hearing required for the individual.

A method of stimulating sensory nerves is disclosed that comprises the steps of providing an electrode plate with a pattern of needle-like (NL) electrodes and conductive plate (CP) electrodes disposed on a front face of the plate element, the NL electrodes being configured to apply electrical stimulation to cutaneous Aδ / C fibers, and the CP electrodes being configured to apply electrical stimulation to cutaneous Aβ fibers; mounting the electrode plate on a patient's skin with the front face in an abutting relationship with the patient's skin, the abutting relationship causing the NL electrodes to penetrate the epidermis of the patient's skin; and applying electrical stimulation to the patient's skin via the pattern of NL electrodes and CP electrodes, the electrical stimulation being applied so that Aβ fiber input from the CP electrodes overlaps in time at the patient's spinal cord and / or brain stem with Aδ / C fiber input from the NL electrodes.

A method and device for automatically assessing loss of hearing sensitivity and compression (recruitment) with user defined frequency resolution by means of extrapolated DPOAE I / O functions and ABRs as well as for automatically fitting hearing aids without any cooperation of the subject tested using a device having a display screen attached to a handheld device generating and collecting otoacoustic emission signals and brain stem response signals into a programmed with a clinical audiogram with fitting parameters for hearing aids calculated on the basis of assessed hearing threshold and compression and identifying the type of hearing required for the individual.

A system for monitoring a brain wave response of a fetus in utero, comprises removably connecting an auditory transducer, including at least one biosensor electrode, producing pulsed auditory sounds to a mother's abdomen to detect brain wave activity in a fetus. The transducer is pulsed with one of rectangular waves and tone pips of a selected frequency to emit pulsed audible sounds at predetermined times. The at least one biosensor electrode, including connected amplifier, detects brain stem auditory responses (BAER) of the fetus. For each pulsed audible sound a series of voltage oscillations corresponding to BAER of the fetus are time-locked to the corresponding audible sound. BAER analog output is converted to BAER digital data. A computer-based QEEG (Quantitative EEG) system improves a signal to noise ratio of the BAER digital data using an adaptive optimum filtering algorithm and analyzes the BAER digital data relative to a reference database.

A radio frequency head coil for a magnetic resonance imaging system is provided. The radio frequency head coil includes a body operative to be disposed on a head of a patient, and an extended lip disposed on the body and operative to receive a magnetic resonance signal. At least some of the magnetic resonance signal is emitted by a region of the patient disposed between a brain stem of the patient up to and including a vertebra of the patient.

Adaptive systems and methods for automatically determining and continuously updating stimulation parameters for adjusting ventilation to accommodate a patient's specific physiology, metabolic needs, and muscle state are disclosed herein. Having a closed loop implementation, the system may comprise a controller including a neuromorphic controlled adaptive feed-forward Pattern Generator / Pattern Shaper (PG / PS) assembly, which controls respiratory muscle movement using electrical stimulation. This PG / PS assembly comprises a biomimetic design where the pattern generator includes a neural network mimicking the simplified connectivity pattern of respiratory related neurons in the brain stem to produce a rhythmic breathing pattern frequency and the pattern shaper includes a neural network mimicking the simplified connectivity pattern of neurons to produce a stimulus control signal. This biomimetic design for the controller automatically customizes and continually updates stimulation parameters to achieve a desired breathing pattern and, thereby, slow the development of muscle fatigue.

The invention discloses a novel externally-applied traditional Chinese medicine composition for treating brain stem tumors and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw materials of medicines: redroot gromwell root, musk, borneol, camphor, draconis sanguis, tuckahoe, giant knotweed, herba schizonepetae, cassia twig, rhizoma ligustici wallichii, wild ginger, radix sileris, notopterygium root, peppermint, chrysanthemum, baikal skullcap root, kuhseng, weeping forsythia, honeysuckle, dandelion, indigo naturalis, red peony root, white peony root, tetrandra root, sacred basil, benzoin, rhizoma atractylodis, rhizoma cyperi, rosa banksiae, radix notoginseng, madder, hyacinth bletilla, rhubarb, toad venom, borax, wrinkled gianthyssop, santalwood, lignum aloe, citron, stinkbug, dalbergia wood, Chinese ephedra, dahurian angelica root, sibirian button bur and magnolia flower. The traditional Chinese medicine composition can be prepared into any externally-applied preparation according to a conventional traditional Chinese medicine preparation method. The invention can be used for obviously improving the passage of the functional activities of qi, dispelling wind, dispelling cold, dredging the stasis of the qi and the blood, promoting blood circulation, relieving the stasis of the blood, regulating the flow of the qi, alleviating pain, reducing tumor bodies and improving the symptoms of headache, dizziness, blurred vision, intracranial pressure ascension, hemiplegia, limb numbness and the like and has definite clinical curative effect, obvious curative effect and quick acting. Because of completely adopting the medicines specified by the dispensatory of China for combination and adopting an externally-applied treatment method, the traditional Chinese medicine composition has the advantages of less stimulation to the skin, low cost, no toxic or side effect basically and the like.

The invention discloses a device for evoking a brain stem frequency following reaction through electrical stimulation and a verification method. The device comprises an evoking potential recorder, the triggering signal output end of the evoking potential recorder converts input single path of signals into two paths of signals through a signal converter to control a channel (1) and a channel (2) of a generator, and electrical stimulation signals in the channel (1) and the channel (2) are opposite in polarity; the channel (1) and the channel (2) are connected to a stimulation electrode through an electrical stimulation signal isolator; the positive pole of the stimulation electrode is used for placing a round window niche of a user, and the negative pole of the stimulation electrode is used for making subcutaneous contact with the osseous external auditory canal; the positive pole of the evoking potential recorder is used for being placed in the center of a connecting line of the binaural calvarium of the user, the negative pole of the evoking potential recorder is used for making subcutaneous contact with the opposite side mastoid process of the user, and a reference electrode of the evoking potential recorder is used for making subcutaneous contact with the nasal tip of the user; the evoking potential recorder is connected with a signal processing module. The device can successfully evoke the brain stem frequency following reaction for an animal with the auditory periphery injured.

The invention belongs to the field of pharmacy and relates to a new application of a traditional Chinese medicine motherwort extract in pharmacy, in particular to the application of the purified motherwort extract in preparing nerve protection medicine for treating cerebral injury, especially the application of the purified motherwort extract in preparing brain protection medicine for treating artery obstruction in the brain. By an animal experiment of the purified motherwort extract, a result indicates that the brain stem volume is obviously reduced after the purified motherwort extract is applied, the obstacle grading of the nerve function is decreased by being compared with a contrast group, the total antioxidant concentration in plasma is increased, the DNA oxidation injury is reduced, the expression levels of apoptosis and apoptosis promoting protein are reduced, and the content of apoptosis resistance protein is also increased. The purified motherwort extract can be used for preparing the nerve protection medicine for treating the cerebral injury and can effectively treat cerebral apoplexy.

The present invention relates to brain tissue sampling method, and is especially ox brain tissue sampling method. The technological scheme of the present invention includes the following steps: 1. locating the sampling range 1-2 cm before the midpoint of ox horn root line; 2. drilling hole through the ox skull in the location; and 3. puncturing with a biopsy needle and sampling the required giant brain, little brain or brain stem tissues. The method of the present invention is simple, convenient and accurate.

The invention provides a facial spasm model based on MR images and a preparation method thereof, and the method comprises the steps: obtaining 3D high-resolution MRI scanning images of facial auditory nerves, adjacent blood vessels and brain stem through an MR nerve imaging sequence, importing the obtained original image data into modeling post-processing software, carrying out the image fusion, segmentation and reconstruction of the pressed facial auditory nerves, responsibility blood vessels and adjacent brain stem structures to obtain the three-dimensional anatomical model of facial spasm nerve vessel compression, and putting the three-dimensional anatomical model of facial spasm nerve vessel compression in a color 3D printer to print an individualized 3D printed solid model. The facial spasm nerve vessel compression form, degree, complex walking and front-back and up-down space relations of adjacent structures are effectively displayed, and the requirements of precise medical evaluation and operations are met. The model is used for preoperative planning, operation simulation and teaching training, reduces the exploration time in the micro-vascular decompression operation, reduces the operative complications, and improves the teaching effect of medical training.

The present invention discloses an electrical stimulation method for observing rat craniotomy motor cortex with the adjustable waveform and amplitude. The method is characterized in that: the motor area of the cerebral cortex is an advanced nerve center for regulating the body motor function, and, through the downward pathway of the pyramidal and extrapyramidal system, controls activities of the brain stem and spinal motor neurons, so as to control muscle movement. Corresponding effects occur after cortical electrical stimulation, experimenters attempt to, through the electrical stimulation of the motor area of the cerebral cortex, cause the effect of body movement, and observe the phenomenon of functional localization of the motor area of the cortex. The rat is fixed to a stereotaxic apparatus, the bone windows are opened, a cortical electrical stimulation using microelectrode is performed, and the electrode is inserted vertically into the position 1.8 mm below the cortex, and adjusted within a range of + / - 200 um so as to cause the maximum movement of the contralateral forelimb, facial hair and neck corresponding to the stimulation points. An electrical stimulator with the adjustable waveform and amplitude is further produced, is capable of accurately completing the experimental observation of electrical stimulation predetermined by experimenters, and provides technical support for the experiment.

Use of a CB1 receptor antagonist and / or inverse agonist, preferably rimonabant, for the preparation of drugs useful for increasing motor neuron excitability in the cerebral cortex and / or in the brain stem and / or at the spinal level, as well as a method for increasing motor neuron excitability through the administration of a CB1 antagonist / inverse agonist receptors, and to the use of a pharmaceutical composition which comprises a CB1 receptor antagonist and / or inverse agonist, preferably rimonabant, for increasing motor neuron excitability in the cerebral cortex and / or in the brain stem and / or at the spinal level.

The present invention is directed to a non-human mammal with at least 30% of all of its glial cells in its corpus callosum being human glial cells and / or at least 5% of all of its glial cells in the white matter of its brain and / or brain stem being human glial cells. Methods of producing and using the non-human mammal are also disclosed.

The invention provides a fixing device of a fish auditory brain stem electrode and an application of the fixing device to collecting a fish auditory brain stem electrical signal. The fixing device comprises an n-shaped elastic fixing strap, wherein two fixing buttons and two magic buttons are also arranged on the n-shaped elastic fixing strap; an electrode stabilizing base is arranged on the n-shaped elastic fixing strap; an elliptic latticed hollow silica gel cushion is mounted at the center position of the electrode stabilizing base; a silica gel liner is arranged on the periphery of the latticed hollow silica gel cushion; and the fixing device also comprises an electrode fixer for fixing an electrode to the electrode stabilizing base. The invention also provides the application of the fixing device to collecting the fish auditory brain stem electrical signal. The fixing device disclosed by the invention can be suitable for heads of fish in different shapes, and can fix and protect the brain stem electrode located to a skull of the fish, an electrode inserted in the skin of the head of the fish can be effectively fixed and protected, and high-precision requirements of potential measurement of auditory brain stem response of the fish are met.

The invention provides a trigeminal neuralgia model based on an MR image and a preparation method of the trigeminal neuralgia model. Through an MR nerve imaging sequence, 3D high-resolution MRI scanning images of trigeminal nerves, adjacent blood vessels and a brain stem are acquired; acquired original image data are imported into modeling post-processing software; image fusion, segmentation and reconstruction are performed on the pressed trigeminal nerves, offending arteries and an adjacent brain stem structure to acquire a trigeminal neuralgia nerve blood vessel compression three-dimensionalanatomical model; a color 3D printer can be imported to print an individualized 3D printing solid model; a nerve blood vessel compression form and degree, complex walking and front and back as well as upper and lower spatial relationships of an adjacent structure are effectively displayed; the needs of accurate medical assessment and an operation are met; the trigeminal neuralgia model is used for preoperative planning, operation simulation and teaching training; the exploration time in a microvascular decompression operation is reduced; operation complications are reduced; and a medical training teaching effect is improved.