The invention relates to the field of location and particularly relates to a location implementation method based on an RFID (Radio Frequency Identification) indoor positioning device. Position coordinates of three known RFID beacons are respectively (x1, y1), (x2, y2) and (x3,y3). The location implementation method comprises the following steps of setting current position coordinates of a first RFID reader to be (x, y) and the distances between the first RFID reader and the three RFID beacons to be d1, d2 and d3, and calculating the values of d1, d2 and d3 by adopting a distance computing method based on time of arrival (TOA); and calculating the position coordinates of the RFID reader by adopting a trilateration method according to the distances d1, d2 and d3 between the first RFID reader and the three RFID beacons, and further carrying out indoor location. The location implementation method is applied to the fields of position management of schools for students, position service of convention centers for exhibits and the like and can also realize anti-theft monitoring for indoor articles by slight improvement.