The invention discloses an air tightness detection device, which relates to the mechanical field and includes a frame, a test cavity, a vacuum generator, a leak detector, a flow controller, a flow sensor, an air pressure sensor and a fixture assembly. The frame The upper part is the test area, and the lower part of the rack is the equipment installation area. The vacuum generator, leak detector, flow controller, flow sensor, and air pressure sensor are all installed in the equipment installation area, and the fixture assembly is installed in the test area. And it is used to fix the test cavity, and the products to be tested are installed in the test cavity. The present invention integrates a plurality of testing devices in one frame, and at the same time, it is equipped with corresponding fixture assemblies to realize the diversification of customer products. The overall structure is compact, the integration is high, and the visual detection work is realized.