The utility model relates to the related technical field of clamping mechanism, specifically is a kind of workpiece detection with clamping mechanism of multi-angle adjustment, including bottom frame, be provided with sliding plate on bottom frame, the top of sliding plate is provided with first rotator through telescopic part and mounting hole, the output of first rotator is connected with first connecting plate through first rotary rod, and the side end of first connecting plate is connected with the outer wall of concave frame, mounting sleeve is provided with in concave frame through second rotary rod, third rotator is installed in mounting sleeve, and the output of third rotator is connected with the middle part of one side of clamping frame, the other side of clamping frame is provided with fixed clamping plate and movable clamping plate, the position of movable clamping plate on clamping frame is adjustable, after being quickly clamped and fixed to workpiece by clamping frame, again through each movable component cooperation, the multi-angle adjustment of clamping frame can be realized.