The invention discloses an intelligent evacuation indication system with a positioning function. The system comprises a controller module, wherein an input end of the controller module is bidirectionally and electrically connected with a comprehensive detection unit, and the comprehensive detection unit comprises an oxygen detection module, a smoke alarm module, a visibility detection module, a temperature detection module and a harmful gas detection module. According to the system, the controller module, the comprehensive detection unit, the oxygen detection module, the smoke alarm module, the harmful gas detection module, the main line power supply module, the emergency communication module, the wireless transceiver module, the wireless positioning module, the fire protection module, the wireless communication module, the terminal processing module and the central monitoring display module are cooperatively used; the system is high in intelligent degree, facilitates remote voice communication and monitoring with trapped persons, can indicate escape routes for the trapped persons in time, facilitates rapid positioning of persons difficult to evacuate, and greatly saves search and rescue time.