The invention relates to an eczema-removing buttock-protecting cream and a preparation method thereof. The eczema-removing and buttock-protecting cream is added with bark extract of Phellodendron bark, Coptidis root extract, Sophora flavescens root extract, A. Cnidium fruit extract, Zanthoxylum rind extract, Camphor tree root and / or stem extract, Gentian root extract, Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, tea leaf extract, Glycyrrhiza glabra root extract A variety of natural plant extracts, including chamomile flower extract, rosemary leaf extract, comfrey root extract, etc., can clear away heat and dampness, kill insects and relieve itching, sores and swelling, and can effectively repair eczema. Skin damage, strengthen the skin barrier, and enhance the skin's defense against external stimuli. The invention has remarkable effects of removing redness and swelling and relieving itching, and does not leave scars after being cured. Moreover, the source of raw materials is extensive, the quality is controllable, and the cost is low.