The invention relates to the technical field of
drug sustained release, and particularly discloses a temperature-sensitive hydrogel microneedle array
drug sustained release method based on
electronic feedback, which comprises the following steps: preparing a temperature-sensitive hydrogel precursor solution to obtain a pre-prepared
mixed solution; injecting the pre-prepared
mixed solution into a microneedle mold to form a
drug-loaded temperature-sensitive hydrogel microneedle array; conducting films are electrically deposited on the surface of the initial micro-needle array and the micro-needle channel, and an
electric control micro-permeable film micro-needle array is obtained; attaching the electrically-controlled micro-permeable membrane micro-needle array to the surface of the
skin to obtain an adjusted micro-permeable array; when the local temperature of the
human body reaches a second preset threshold value, the adjusted micro-transparent array releases the
medicine; according to the invention, a plurality of independent chambers are arranged in the same microneedle array and are respectively loaded with
traditional Chinese medicine nano preparations with different functions, so that directional release of each component in respective optimal environments can be realized. Active substances such as the middle-jiao-regulating
pill extract, the health-care
pill extract,
tetrahydropalmatine and the like are free from compatibility conflict, so that the maximum
exertion of respective drug effects is ensured.