The invention provides a method and system for guaranteeing safe operation of a power supply system, which includes collecting video information of an operation site; video frame extraction, image preprocessing and recognition analysis being carried out on the video information, which comprises the following steps: identifying the identity of the operator by using the face recognition technology;using positioning technology to track the trajectory of the operator; using the image processing technology to distinguish the safety violation behavior of the operators; using image processing technology to inspect the quality of the workers' work; according to the analysis results, if unauthorized non-operation personnel, and/or operation personnel break into the restricted area, and/or the operation personnel fail to close the equipment cabinet door as required, and/or the operation personnel commit safety irregularities, and/or the operation quality of the operation personnel does not meetthe acceptance standard, the alarm prompt and/or record being issued. The present application is capable of providing a strong foundation for safe operation of a power supply system in a more scientific and intelligent manner.