The invention relates to an individualized reversal design and manufacturing method for a full knee joint replacing prosthesis. The method comprises the following steps that 1, three-dimensional digital models of the thighbone and the tibia are built on the basis of the medical image data of the knee joint of a patient; 2, virtual bone cutting software is used for respectively carrying out simulated bone cutting on the three-dimensional digital models of the thighbone and the tibia; 3, the reversal design of CAD (computer-aided design) models of a thighbone replacing prosthesis, a tibia replacing prosthesis and a tibia gasket prosthesis is carried out; 4, the full knee joint replacing prosthesis is manufactured according to the CAD models of each prosthesis through the 3D (three-dimensional) printing technology. The method provided by the invention has the advantages that on the basis of the original bone structure of the patient, the virtual knee joint replacing operation bone cutting form is combined, the structural form of the replacing prosthesis is subjected to reversal design, the structural form consistency of the cut bone and the replacing implanted body structure is realized to the greatest degree, and the optimum matching between the prosthesis and the individual bone form is reached. In addition, the laser selective melting 3D printing technology is used for manufacturing the designed replacing prosthesis, the optimum matching between the prosthesis and the knee joint bone cutting surface is ensured on the basis of the minimum bone cutting quantity, and the effect optimization is reached.