41 results about "Positron Emission Tomography Scan" patented technology

Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are disclosed.

Novel epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors, pharmaceutical compositions including same and their use in the treatment of EGFR-TK related diseases or disorders are disclosed. Novel radiolabeled EGFR-TK irreversible inhibitors as their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharmaceuticals for radiotherapy are further disclosed.

A method for labeling structures, such as β-amyloid plaques and neurofibrillary tangles, in vivo or in vitro, is provided and comprises contacting brain tissue with one or more compounds, preferably radiolabeled for detection by positron emission tomography (PET).

A device and method for on-line correction of patient motion in three-dimensional positron emission tomography. The devices encompass an on-line hardware pipelining architecture to support 3D translation, normalization, and weighted histogramming as required. Five stages of processing for the PET event stream are utilized in the present invention. Each stage feeds the next with progressively modified event packets proceeding at a processing speed of at least 10M packets / sec. Stage 1 calculates an event correction factor (ECF) for each incoming detector-pair event packet. This ECF is incorporated into the event packet for use later in Stage 5. Stage 2 converts the detector-index-pair content of each packet into (x,y,z) pair content. Specifically, the representation of each detector element is converted from a discrete crystal index into a 3-D coordinate index. Stage 3 transforms the (x,y,z) pair into an (x′,y′,z′) pair. Stage 4 converts the (x′,y′,z′) pair into a bin address. Output from Stage 5 is a normalized projection data set available at the end of each acquisition frame. Stage 5 performs on-line weighted histogramming.

A device and method for on-line correction of patient motion in three-dimensional positron emission tomography. The devices encompass an on-line hardware pipelining architecture to support 3D translation, normalization, and weighted histogramming as required. For the 3D translation circuit, a first digital pipeline latch is provided for receiving data as it is collected by the PET scanner. A bank of multiplier circuits receives the PET scan data. Each multiplier circuit receives and multiplies a portion of the entire scan data simultaneous with each other multiplier circuit. The product of each multiplier circuit is output to a second digital pipeline latch. The data is then passed to a bank of adders, each of which supports four input variables. While a specific LOR and a current object orientation are input to the first digital pipeline latch, processing for a different LOR and an earlier object orientation are stored in the second digital pipeline latch. Additionally, fully transformed coordinates from a third LOR are loaded into a third digital pipeline latch. As the banks may each complete their respective tasks under a threshold time limit, the pipelining technique permits the entire 3D transformation for the AB pair to take place in real time. Further, on-line normalization and on-line weighted histogramming are also performed in real time.

Embodiments of the present invention provide methods and apparatus for imaging a tissue specimen excised during surgery with a combined positron emission tomography (PET) and micro computed tomography (micro CT) scanner. The specimen is scanned with a CT imaging system of the combined PET and micro CT scanner. The specimen is also scanned with a PET imaging system of the combined PET and micro CT scanner. A PET image is constructed based on data acquired by the PET imaging system. A micro CT image is constructed based on data acquired by the micro CT imaging system. The micro CT image includes at least one visualization of a lesion marker.

A method for positron emission tomography (PET) imaging of LRRK2 in tissue of a subject, the method comprising: administering a compound of formula I, formula II or formula III, or a pharmaceutically acceptable salt thereof to the subject, wherein the compound includes at least one C11 or F18 label thereon; allowing the compound to penetrate into the tissue of the subject; and collecting a PET image of the CNS or brain tissue of the subject

New types of nanoparticle-based dual-modality positron emission tomography / magnetic resonance imaging (PET / MRI) and positron emission tomography / computed tomography (PET / CT) tumorspecific contrast agents have been developed. The base of the new type contrast agents is biopolymer-based nanoparticle with PET, MRI and CT active ligands. The nanoparticle contains at least one polyanion and polycation, which form nanoparticles via ion-ion interaction. The self-assembled polyelectrolytes can transport gold nanoparticles as CT contrast agents, or SPION or Gd(III) ions as MRI active ligands, and are labeled using a complexing agent with gallium as PET radiopharmacon. Furthermore, these dual modality PET / MRI and PET / CT contrast agents are labeled with targeting moieties to realize the tumorspecificity.

A method and system for providing improved timing calibration information for use with apparatuses performing Time of Flight Positron Emission Tomography scans. Relative timing offset, including timing walk, within a set of processing units in the scanner are obtained and corrected using a stationary limited extent positron-emitting source, and timing offset between the set of processing units is calibrated using an internal radiation source, for performing calibration.

The present invention is directed to benzazepin-1-ol-derived compounds for use in the diagnosis of NMDA receptor-associated diseases or disorders by positron emission tomography (PET). The invention also relates to a method for the diagnosis of NMDA-receptor-associated diseases or disorders by administering to a patient in need of such diagnosis a radioactively labelled compound of the invention in an amount effective for PET imaging of NMDA receptors, recording at least one PET scan, and diagnosing an NMDA-receptor-associated disease or disorder from an abnormal NMDA receptor expression pattern on the PET scan. NMDA-receptor-associated diseases or disorders that can be diagnosed with the radioactively labelled benzazepin-1-ol-derived compounds include but are not limited to neurodegenerative diseases or disorders, Alzheimer's disease, depressive disorders, Parkinson's disease, traumatic brain injury, stroke, migraine, alcohol withdrawal and chronic and neuropathic pain.

A method is described for acquiring and analysing the data produced by Positron Emission Tomography (PET), which method provides for an accurate estimation of vascular compartment volume, VB. An MRI scan and the PET scan is performed simultaneously and the results of the former is used to derive a value for VB. The value so derived is then used in pharmacokinetic modelling along with the results of the functional scan.

This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled with 64Cu or 18F. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.

The invention relates to a system and method for enhancing image data obtained from a positron emission tomography (PET) scan. In various embodiments, the method comprises transforming an original image data set to provide a first modified image data set by performing a masked volume-wise principal component analysis (MVW-PCA) on the original image data set. The first modified image data set is then transformed to provide a second modified image data set by performing a masked volume-wise independent component analysis (MVW-ICA) on the first modified image data set, the second modified image data set thereby comprising enhanced image data.

The present disclosure relates to an apparatus for estimating scatter in positron emission tomography, comprising processing circuitry configured to acquire an emission map and an attenuation map, each representing an initial image reconstruction of a positron emission tomography scan, calculate, using a radiative transfer equation (RTE) method, a scatter source map of a subject of the positron emission tomography scan based on the emission map and the attenuation map, estimate, using the RTE method and based on the emission map, the attenuation map, and the scatter source map, scatter, and perform an iterative image reconstruction of the positron emission tomography scan based on the estimated scatter and raw data from the positron emission tomography scan of the subject.

This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for therapy and diagnostic imaging by positron emission tomography (PET).

The present disclosure relates to an apparatus for estimating scatter in positron emission tomography, comprising processing circuitry configured to acquire an emission map and an attenuation map, each representing an initial image reconstruction of a positron emission tomography scan, calculate, using a radiative transfer equation (RTE) method, a scatter source map of a subject of the positron emission tomography scan based on the emission map and the attenuation map, estimate, using the RTE method and based on the emission map, the attenuation map, and the scatter source map, scatter, and perform an iterative image reconstruction of the positron emission tomography scan based on the estimated scatter and raw data from the positron emission tomography scan of the subject.

There is provided a process for the preparation of a pharmaceutical composition comprising an 18F-labelled gas selected from the group consisting of 18F-labelled sulphur hexafluoride ([18F]SF6) and 18F-labelled carbon tetrafluoride ([18F]CF4), comprising the steps: a) Filling a target with a gas mixture comprising a fluorinated gas selected from the group consisting of sulphur hexafluoride (SF6) and carbon tetrafluoride (CF4); b) Irradiating the gas mixture of step a) with protons with energies from 0.1 to 50 MeV. The pharmaceutical composition obtainable by the process and its uses in diagnosis, prognosis and lung function studies based on positron emission tomography (PET) are also claimed.

Methods and reagents for labeling synthesis of organohalides by transition metal mediated carbonylation reactions using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled organohalides are useful as radiopharmaceuticals, especially for use as precursors in Positron Emission Tomography (PET). Associated PET tracers and kits for PET studies are also provided.

Embodiments of the invention are directed to a method for providing an attenuation map of a patient, a method for providing corrected PET data of the patient acquired with combined magnetic resonance / positron emission tomography imaging in a magnetic resonance / positron emission tomography system, a computer positron emission tomography facility and an associated computer program product. A methodis for providing an attenuation map of a patient, suitable for correcting PET data of the patient acquired with combined magnetic resonance / positron emission tomography imaging in a magnetic resonance / positron emission tomography system. In an embodiment, the method includes acquiring magnetic resonance data in the magnetic resonance / positron emission tomography system; determining the attenuationmap of the patient using the magnetic resonance data and providing the attenuation map of the patient for correcting the PET data of the patient acquired with combined magnetic resonance / positron emission tomography imaging.

A method and apparatus are provided for reconstructing list mode data acquired during a positron emission tomography scan of an object, the data including information indicative of a plurality of detected positron annihilation events. Detected events occurring in a region of interest are identified; the identified events are reconstructed using an iterative reconstruction technique which includesa ray tracing operation to generate volumetric data indicative of the region of interest, wherein the ray tracing operation traces only image matrix elements located in the region of interest; and a human readable image indicative of the volumetric data is generated. In another aspect an image mask and a projection mask are defined correlating to the region of interest; image matrix elements located in the region of interest are determined by applying the image mask; and detected events occurring in a region of interest are identified by applying the projection mask.

A method for normalization of a positron emission tomography (PET) scanner. The PET scanner includes a plurality of blocks. Each of the plurality of blocks includes a plurality of rows. Each of the plurality of rows includes a plurality of actual detectors and an unused area. The method includes acquiring a plurality of lines of response (LORs) by scanning a normalization phantom, obtaining a plurality of actual counts by extracting a plurality of LORs subsets from the plurality of LORs and counting a number of elements in each LORs subset, generating a plurality of virtual detectors in each of the plurality of rows by assigning the unused area to the plurality of virtual detectors, generating a count profile for the plurality of actual detectors, estimating a plurality of virtual counts based on the count profile, and applying a normalization process on the plurality of blocks.

Disclosed is a method for producing a fluorine-18-labeled, translocator protein overexpression-targeting PET radiotracer including: preparing a fluorine-18 reaction solution; producing a ((4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl) (aryl)iodonium) anion precursor as an iodonium salt precursor; producing a 2-(6,8-dichloro-2-(4-(4,4,5,6-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)imidazo[1,2-a]pyridin-3-yl-N,N-dipropylacetamide precursor as a boron ester precursor; producing an iodonium salt precursor reaction solution; preparing a boron ester precursor reaction solution; and producing a radiotracer composition containing a fluorine-18-labeled radiotracer by reacting the iodonium salt or boron ester precursor reaction solution with the fluorine-18-labeled reaction solution. The use of the fluorine-18-labeled PET radiotracer makes it possible to diagnose patients with various brain diseases and tumors by obtaining new images of neuroinflammation, stroke and tumors associated with translocator protein overexpression through PET. In addition, by virtue of the long half-life of fluorine 18, the PET radiotracer can provide brain neuroinflammation and tumor imaging diagnostics to a larger number of patients compared to conventional carbon-11 tracers.

The present invention provides a novel method for the preparation of 18F-fluoride (18F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of 18F-labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk solutions are prepared and stored in prefilled vials rather than being freshly prepared on the day of synthesis. Also provided by the present invention is a radiofluorination reaction which comprises the method of the invention, as well as a cassette for use in carrying out the method of the invention and / or the radiofluorination method of the invention on an automated radiosynthesis apparatus.

The present invention relates to a method for providing an attenuation map of a patient, a method for providing a corrected PET detected in a combined magnetic resonance-positron emission tomography scan of a patient in a magnetic resonance-positron emission tomography facility. data, a computerized positron emission tomography facility and an associated computer program product. The method according to the invention for providing an attenuation map of a patient is suitable for correcting PET data of a patient detected in a combined magnetic resonance-positron emission tomography scan in a magnetic resonance-positron emission tomography facility, said method comprising The following steps: detecting magnetic resonance data in a magnetic resonance-positron emission tomography facility, using the magnetic resonance data to derive an attenuation map of the patient, and providing an attenuation map of the patient for use in correcting the patient's combined magnetic resonance-positron emission tomography scan Attenuation plot of PET data detected in .