The invention discloses a liquid crystal compound containing fluoropyrimidine and application thereof. The compound has the following structure, wherein R is C1-C8 alkyl or alkenyl, or fluorine-containing C1-C8 alkyl or alkenyl; X is a hydrogen group or a fluorine group; Z is one of the C1-C8 alkyl, the fluorine group, difluoromethyl, trifluoromethyl, trifluoromethoxy, difluoromethoxy or pentafluoroethyl. The compound has higher optical refractive index anisotropy (delta n), lower threshold voltage, wide liquid crystal phase temperature range, good optical, thermal, electric and chemical stabilities, and good compatibility with other compounds, can be used for improving the characteristics of a liquid crystal mixture, can be widely applied to mixed liquid crystal materials of TN, HTN, STN and TFT, and can be further applied to liquid crystal displays.