The present invention provides a feedback controlled bioculture platform for use as a precision
cell biology research tool and for clinical
cell growth and maintenance applications. The
system provides individual closed-loop flowpath cartridges, with integrated, aseptic sampling and routing to collection vials or analysis systems. The
system can operate in a standard laboratory or other
incubator for provision of requisite gas and thermal environment.
System cartridges are modular and can be operated independently or under a
unified system controlling architecture, and provide for scale-up production of
cell and cell products for research and clinical applications. Multiple replicates of the flowpath cartridges allow for individual, yet replicate
cell culture growth and multiples of the experiment models that can be varied according to the experiment design, or modulated to desired cell development of
cell culture end-points. The integral flowpath
cartridge aseptic sampling
system provides for dynamic analysis of metabolic products or representative cells from the culture.