The invention relates to a nutritional supplement with effects of relieving alcoholism and protecting livers, and a preparation method of the nutritional supplement, and belongs to the technical field of food processing and preparation. The nutritional supplement with the effects of relieving alcoholism and protecting livers comprises the following raw materials in percentage by weight: 10.00-40.00% of maltodextrin, 10.00-35.00% of enzymolysis oat powder, 8.00-25.00% of whey protein, 5.00-50.00% of granulesten, 1.00-10.00% of phosphatidylcholine, 2.00-5.00% of dietary fibers, 1.00-5.00% of casein phosphopeptides, 0.10-0.50% of chicken powder, 0.10-0.50% of beef powder, 0.10-0.50% of carrot powder, 0.10-0.50% of lotus root powder, 0.10-0.50% of Chinese wolfberry powder, 0.10-0.50% of celery powder, 0.10-0.20% of composite vitamins, and 0.50-2.00% of composite minerals. According to the nutritional supplement, the phosphatidylcholine is particularly added, so that the nutritious ingredients are comprehensive; besides, the main ingredients have the effects of complementing and efficiency improvement on the function of auxiliary protection for chemical liver injury, which has an important significance in improving the health conditions of Chinese residents.