The invention discloses a darunavir midbody as well as a preparation method and application thereof. The midbody has a chemical structure shown by a formula II which is as shown in the specification. The preparation method of the midbody comprises the step b or step a-b of the synthetic route, wherein X is selected from Cl, Br or I, R is selected from aryl or alkyl, and R1 is selected from the alkyl of C1-C4. The midbody can be used for preparing the key midbody of darunavir, namely, hexahydrofuran-[2,3-b] furan-3-alcohol and (3R,3aS,6aR) hexahydrofuran-[2,3-b] furan-3-alcohol. The midbody has the advantages of using cheap and easily-available raw materials, being simple to prepare, having low cost, and being applicable to large scale production, thus having significance and practical value to realization of industrial production of darunavir.