The invention discloses a method for detecting remote sensing image change based on interest areas, which belongs to the fields of analyzing and processing remote sensing images. The invention mainly solves the problems of pseudo-change information existing in the methods for detecting remote sensing image change, the implementation process comprises: firstly, extracting the outline of a differential chart, secondly, defining the outline map of a closed interest area based on the threshold value outline map chained method, and obtaining the interest area after expanding the outline, thirdly, obtaining a new differential chart through updating the differential chart according to the gray level, the space position and the sort feature of the interest area and a non-interest area, fourthly, dividing the interest area in the new differential chart, and obtaining a change result chart. The method has the advantages of accurate location of the interest area, noise and registration error robust, less pseudo-change information and high change detection, and can be used in the fields of disaster surveillance, land utilization and agriculture investigation.