The invention provides a manufacture method of a three-dimensional simulation model used for underground mining, belonging to the manufacture of mine three-dimensional models; the manufacture method adopts module-typed three-dimensional structure and manufactures the landform, physiognomy, geological structure and all production systems of a certain mine into corresponding modules and organically combines the modules into solid models; types such as transparent type, half-transparent type and non-transparent type and forms such as horizontal form, vertical form, inclined form and local tunnelling type are adopted so as to manufacture the corresponding three-module modules according to a certain proportion; a method with the types such as vertical cover-opening type, horizontal butting type, inclined surface overlapping type and local removal type is adopted so as to organically combine all the functional modules into an integral model; the manufacture method of the invention can comprehensively, intuitively, clearly and exactly reflect the landform, physiognomy and geological structure in the well field range, and the mutual relation and corresponding spatial positions of all the production systems above/below the well, and is applicable for mine development, safe production management and safe production technique training of the underground mining of coal mines, metal mines and non-metal mines.