The invention relates to a method for predicting a low-porosity and low-permeability clasolite effective reservoir at a high-diagenesis stage and belongs to the technical field of oil and gas exploration and development. The method is characterized in that a geological process response relationship is established through carrying out analysis, simulation and quantitative evaluation on a geological process affecting porosity, the original pore preservation and induced pore increase/decrease conditions of a reservoir are determined, thus, the current porosity of a low-porosity and low-permeability reservoir at the high-diagenesis stage is quantitatively evaluated, the development of the effective reservoir is predicted, and a basis is provided for reservoir evaluation. The method for predicting the low-porosity and low-permeability clasolite effective reservoir at the high-diagenesis stage has the advantages that the predictability is strong, the distribution of various clasolite effective reservoirs at different stages of high-diagenesis can be accurately predicted, the fine prediction on the distribution of effective reservoirs of a research target section can be achieved, and the predicted unit plane can reach a hectometer level; the theoretical basis is solid, and the condition of over reliance on the data of sampled points in the traditional method is avoided; the quantitative performance is good, the applicability is wide, and the information requirements are relatively low; and the evaluation, with different information foundations, on different exploration and development stages is facilitated.