The present invention discloses a formula of wild taisui (slime mold compound) health-care wine and a preparation method of the formula. The formula is prepared from the following raw materials in parts by weight: 950-1,050 parts of wild taisui (slime mold compound), 8-12 parts of fructus amomi, 8-12 parts of lily bulbs, 8-12 parts of highland barley, 10-12 parts of rose flowers, 8-12 parts of round cardamom fruits, 8-12 parts of radix ophiopogonis, 0.5-1 part of taxus wallichiana var. chinensis, 0.5-1 part of menthol, 8-12 parts of radix astragali, 95-105 parts of walnut kernels and 2,500-3,000 parts of baijiu of 45-65 degrees. The formula has advantages of simple formula, multiple functions, etc., and has very high practical value and promotion value in the technical field of wild taisui(slime mold compound) health-care wine.