The invention designs a device for realizing acoustic agglomeration emission reduction of fine particles in high-flow flue gas of a burning energy system. The device comprises a high-pressure gas flow source, a high-pressure gas mixing chamber, gas flow sound sources, a horn, a coupling cabin, an agglomeration cabin, an extended cabin, a movable end surface, a conventional dust remover, a data sensing control part, a central measurement and control computer, a sound elimination part and a sound insulation part. According to the device, the three high-power gas flow sound sources are matched with a variable-section pipeline by fully utilizing the principle that the acoustic agglomeration efficiency is sharply improved along with the increment of the sound pressure level; a barrier structure and a gas-sound separation part are introduced, so that the fine particles are quickly agglomerated in the large-size agglomeration cabin under the action of a high-strength and low-harmonic-component planar standing wave sound field; running parameters are adjusted and optimized in a unified manner by virtue of the measurement and control computer; the best transmission efficiency of strong sound waves from generating to acting is realized and the characteristic change of the fine particles is adapted; the whole realization scheme has the advantages of emission reduction efficiency, economical efficiency, applicability, no pollution, extendability and the like.