The invention discloses a liquid crystal display color difference detection device and method, comprising a main casing, a sealed door, a connecting plate, a fixing bolt, a first electric push rod, a supporting plate, a supporting leg, a guiding cylinder, a guiding block, a guiding rod, Fixed plate, second electric push rod, colorimeter body, fixed column, fixed rod, rotating ring, rotating rod, fixed shell, adjusting bolt, moving block, fixed frame, spring, push rod, splint, placing board. This liquid crystal display color difference detection device and method is simple in structure and novel in design, which is convenient for workers to adjust the placement position of the main shell according to their own needs, and at the same time ensures the stable movement of the main shell during the adjustment process, which is convenient to meet the height of workers. , easy to use, under the action of the set clamping mechanism, it is convenient to stably clamp the LCD screen placed on the surface of the placement board, improve the stability of the LCD screen placement, and facilitate the workers to stabilize the LCD screen during the detection process Fixed, improved detection.