The invention discloses a multifunctional tissue box used in a rest room. The multifunctional tissue box comprises a tissue box body and a hook, a top cover is arranged at the top of the tissue box, afixing base, a cosmetics placing groove, a cigarette placing groove and a tooth glass placing groove are formed in the surface of the top cover, the cosmetics placing groove is formed in one side ofthe cigarette placing groove, one end of the hook fixing base is adhesively connected with the wall of the rest room through adhesive, the other end of the hook fixing base is connected with a throughhole in the tissue box through the hook, and the wall face of the rest room is ensured to be attractive; tissue is placed in the tissue box, one end of the tissue extends out of the connector of thetissue box and a cover plate, saw teeth are arranged on the connector, and therefore a user takes the tissue more conveniently; as the cosmetics placing groove, the cigarette placing groove and the tooth glass placing groove are formed, the use functionality of the tissue box top cover is improved, by arranging the placing grooves, cosmetics, cigarettes and a tooth glass are separated, and it is avoided that adjacent articles are knocked down when the user takes one article above.