The invention relates to a processing method of a large-scale thin-wall cabin shell body. The processing method comprises the steps of 1, reserving a criterion boss on the shape of the shell body when casting the shell body, conducting rough machining on the lineation criterion, leveling a front and back end surfaces of the shell body, and conducting rough machining on the front and back end surfaces of the shell body; 2, conducting rough machining on shape and an inner cavity of the shell body according to the processing criterion in the step 1, conducting aging treatment after the rough machining, and detecting form and location tolerance deformation quantities of the shell body before and after the aging treatment; 3, analyzing remaining quantities of various parts of specially shaped end of the shell body according to a deformation rule of the shell body, judging whether there is a need to borrow quantity, finishing semi-finishing on the shape and the inner cavity of the shell body, and conducting aging treatment after the semi-finishing; 4, detecting the form and location tolerance deformation quantities before and after the aging treatment of the shell body in the step 4, further figuring out the deformation rule of the shell body, and finishing finish machining of the shell body; 5, finally detecting all the sizes of the shell body and storing the shell body into a storage after the shell body is qualified. The invention also relates to a clamp used according to the method. The processing method can improve sharply processing efficiency, guarantee the quality of a product, causes a small processing deformation, and can guarantee the homogeneity of shell wall thickness.