The invention discloses a prevention and control fertilizer for resisting banana wilt and a preparation method thereof. The prevention and control fertilizer comprises 80 to 100 parts of an organic compost, 40 to 50 parts of urea, 30 to 45 parts of a phosphorus fertilizer, 40 to 50 parts of a potassium fertilizer, 10 to 20 parts of nitrohumic acid, 30 to 40 parts of silicon dioxide, 5 to 10 parts of a filling material and 10 to 20 parts of an antagonistic microbial agent. The preparation method comprises the following steps: uniformly mixing an organic fertilizer, and carrying out stacking and fermentation so as to obtain a fermented mixture; naturally cooling the fermented mixture to 25 to 30 DEG C, then adding the urea, the phosphorus fertilizer, the potassium fertilizer and the antagonistic microbial agent into the fermented mixture, and carrying out uniform mixing for refermentation; and crushing the silicon dioxide and the filling material until the particle sizes of the crushed silicon dioxide and filling material are 200 meshes or above, adding the crushed silicon dioxide and filling material powder into a ferment obtained in the step S2, carrying out uniform mixing under stirring, and carrying out granulation and drying in the air so as to obtain the prevention and control fertilizer for resisting the banana wilt. According to the invention, on the basis of reasonably controlling nitrogen and increasing potassium, absorption of bananas to a silicon element is increased; and by combination of the antagonistic microbial agent, the banana wilt is inhibited.