The invention discloses an intelligent medicine service system based on the Internet of things and its working method. The system includes a medicine box, a hospital system platform and an intelligentbracelet; the intelligent bracelet is used for users to wear, the medicine box includes a medicine box body, and the medicine box body is provided with a controller, a touch screen, a key module anda first wireless communication module; the intelligent bracelet includes a microprocessor, a display screen, a vibration module, a body temperature module, a blood pressure detection module, a heart rate detection module and a second wireless communication module, wherein the body temperature module is used for detecting the temperature of the human body, the blood pressure detection module is used for detecting the blood pressure of the human body, and the heart rate detection module is used for detecting the heart rate of the human body; the controller is electrically connected with the touch screen, the key module and the first wireless communication module respectively, and the microprocessor is electrically connected with the display screen, the vibration module, the body temperaturemodule, the blood pressure detection module, the heart rate detection module and the second wireless communication module respectively. The system can remind the users to take medicines when it is time for taking the medicines and monitor the physical conditions of the users after the users take the medicines.