The invention discloses an anticancer dispersing paste and a preparation method thereof on the basis of a secret recipe handed down in the family through repeatedly modifying a formula. The anticancer dispersing paste comprises the following raw materials: 30-60g of scorpion, 30-60 scolopendras, 1 long-noded pit viper, 30-60g of gecko, 30-60g of eupolyphaga, 30-60g of toad skin, 20-50g of rhizomascirpiyagarae, 20-50g of rhizoma zedoariae, 20-50g of artemisia leaf, 20-50g of crinis carbonisatus, 20-50g of scaly anteater, 20-50g of panax pseudo-ginseng var. notoginseng, 20-50g of honeycomb, 20-50g of bistortae rhizoma, 10-30g of nux vomica, 10-30g of frankincense, 10-30g of myrrh, 10-30g of realgar, 10-30g of calamitas urinae hominis and 2-8g of muskiness. The invention has the functions of resisting cancer and dispersing stasis, promoting blood circulation by removing blood stasis, eliminating phlegm and freeing channels, diminishing swelling and releasing pain, and is suitable for treating symptoms of various stages of non-ulcerated cancer, dorsal furuncle, scrofulosis, mammillary nucleus, ovarian cyst, abdominal mass, and the like.