Fibroblast Activator, Collagen Production Promoter, Collagen Contraction Promoter, Hyaluronic Acid Production Promoter, ATP Production Promoter, Melanin Formation Inhibitor, and Agent for External Application to the Skin

Abstract

The present invention is a fibroblast activator, collagen production promoter, collagen contraction promoter, hyaluronic acid production promoter, ATP production promoter or melanin formation suppressor, which contains, as an active ingredient, at least one kind of compound selected from the group consisting of conagenin, a conagenin derivative, and a pharmaceutically acceptable salt thereof, as well as a composition (skin external preparation, cosmetic, pharmaceutical product or food, which is a composition for the improvement of wrinkles or a whitening composition) containing such activator, promoter or melanin formation suppressor.According to the present invention, a safe skin external preparation, cosmetic (cosmetic composition), pharmaceutical product or food, which shows a high wrinkle improving effect, can be provided, and a safe skin external preparation, cosmetic (cosmetic composition), pharmaceutical product or food, which shows a high whitening effect can be provided.

Description

TECHNICAL FIELD[0001]The present invention relates to a fibroblast activator, a collagen production promoter, a collagen contraction promoter, a hyaluronic acid production promoter, an ATP production promoter, a melanin formation suppressor and a skin external preparation, as well as cosmetics, which are safe and highly effective.BACKGROUND ART[0002]With increasing population of aged people in recent years, prevention of skin aging evidenced by wrinkles, pigmented spot and the like that increases with aging, i.e., so-called antiaging, has been actively studied.[0003]The skin is mainly divided into epidermis, dermis and subcutaneous tissue. Particularly, the fibroblast constituting dermis produces proteins such as collagen and the like and glycosaminoglycans such as hyaluronic acid and the like, forms a binding tissue (extracellular matrix), and plays an important role for the homeostasis of the skin.[0004]Collagen is a protein occupying about ⅓ of the protein in a living body, and i...

AI Technical Summary

Benefits of technology

[0030]The skin external preparation and cosmetic of the present invention can be produced by using, where necessary, components and additives used for pharmaceutical product, quasi drug, cosmetic and the like in combination, to the extent that the effect of the invention is not impaired. Specific examples of the addition components include the following.

[0031]Examples of the surfactant include anion surfactants such as soap base, fatty acid soap, higher alkylsulfate, alkyl ether sulfate, N-acylsarcosinate, higher fatty acid amide sulfonate, phosphate, sulfosuccinate, alkylbenzene sulfonate, N-acylglutamate, higher fatty acid ester sulfate, sulfonated oil, POE (polyoxyethylene) alkyl ether carboxylate, POE alkylallyl ether carboxylate, α-olefin sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylol amide sulfate, lauroyl monoethanol amide succinate, N-palmitoyl aspartate ditriethanolamine, casein sodium and the like, cation surfactants such as alkyltrimethylammonium salt, dialkyldimethylammonium salt, alkylpyridium salt, alkylquaternaryammonium salt, alkyldimethylbenzylammonium salt, alkylisoquinolinium salt, dialkylmorpholium salt, POE alkylamine, alkylamine, polyamine fatty acid derivative, amylalcohol fatty acid derivative, benzalkonium chloride, benzethonium chloride and the like, ampholytic surfactant such as imidazoline surfactant, betaine surfactant and the like, lipophilic nonionic surfactants such as sorbitan fatty acid ester, glycerin fatty acid ester, propylene glycol fatty acid ester, hydrogenated castor oil derivative, glycerin alkyl ether, polyoxyethylene• methylpolysiloxane copolymer and the like, lipophilic nonionic surfactants such as POE sorbitan fatty acid ester, POE sorbit fatty acid ester, POE glycerin fatty acid ester, POE fatty acid ester, POE alkyl ether, POE alkyl phenyl ether, POE-POP alkyl ether, tetraPOE•tetraPOP ethylenediamine condensate, POE hydrogenated castor oil derivative, POE beeswax-lanolin derivative, alkanolamide, POE propyleneglycol fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester and the like, and the like.

[0032]Examples of the oils include animal vegetable oil and hardened oil thereof such as avocado oil, olive oil, sesame oil, camellia oil, evening primrose oil, turtle oil, macadamia nut oil, corn oil, mink oil, rapeseed oil, egg-yolk oil, apricot kernel oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, carmelia sinesis oil, Japanese torreya seed oil, rice bran oil, tung oil, jojoba oil, cacao butter, palm oil, horse oil, palm oil, elaesis guineensis kernel oil, beef tallow, mutton tallow, lard, lanolin, whale wax, beeswax, carnauba wax, Japan wax, candelilla wax, squalane and the like, mineral oils such as liquid paraffin, vaseline and the like, synthetic triglycerols such as tripalmitate glycerin and the like, other oily components and the like.

[0033]Examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, oleic acid, linoleic acid, linolenic acid, stearic acid, behenic acid, 12-hydroxystearic acid, isostearic acid, undecyne acid, tall oil acid, eicosapentaenoic acid, docosahexaenoic acid and the like. Examples of the higher alcohol include lauryl alcohol, cetyl alcohol, stearyl alcohol, bechenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, jojoba alcohol, lanolin alcohol, batyl alcohol, 2-decyltetratecesinol, cholesterol, phytosterol, isostearyl alcohol and the like. Examples of the synthetic esters include cetyl octanoate, octyldodecyl myristate, isopropyl myristate, myristyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, decyl oleate, dimethyl octanoate, cetyl lactate, myristyl lactate and the like. Examples of the silicone include chain polysiloxane such as dimethyl polysiloxane, methylphenyl polysiloxane and the like, cyclic polysiloxane such as decamethyl cyclopolysiloxane and the like, one having a three dimensional net structure such as silicone resin and the like, and the like.

[0034]Examples of the moisturizing agent include glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyethylene glycol, hexylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfuric acid, hyaluronic acid, mucoitinsulfuric acid, atelocollagen, urea, sodium lactate, bile salt, dl pyrrolidone carboxylate, soluble collagen, atelocollagen, collagen resolvent, hyaluronic acid, hyaluronic acid resolvent, nucleic acid and the like, as well as various animal and plant extracts, yeast extract and the like.

[0035]Examples of the UV absorber include benzoic acid UV absorbers such as paraamino benzoic acid, paraamino benzoic acid derivative and the like, antranilic acid UV absorbers such as homomentyl N-acetylanthranilate and the like, salicylic acid UV absorbers such as amyl salicylate and the like, cinnamic acid UV absorbers such as octyl cinnamate and the like, benzophenone UV absorbers such as 2,4-dihydroxybenzophenone and the like, 4-methylbenzylidenecamphor, 3-benzylidenecamphor, 2-phenyl-5-methylbenzoxazole, nucleic acid and the like.

Problems solved by technology

Furthermore, since collagen decreases as one grows old, it is considered one cause of angioembrittlement, decreased inelasticity and flexibility of the skin and the like.

Particularly, with regard to the skin, it is known that the action of fibroblast becomes weak as one grows old, which weakens the power of the cells to pull collagen fiber (collagen contraction force), resulting in inelasticity of the skin and sagging.

While many cosmetics containing, as an aged skin-improving agent, collagen or hyaluronic acid have been proposed, they merely improve surface-moisturizing effect, and do not essentially improve the aging skin.

As the situation stands, however, the treatment of aging skin has not been accomplished yet.

On the other hand, such aging symptoms of human skin, particularly wrinkles and sagging, are also considered to mainly occur due to the degraded function of skin fibroblast and insufficient secretion of matrix fiber and collagen due to degraded function of the cells.

However, the fibroblast activators so far reported have failed to afford an effective result because they show high effective concentration, poor fibroblast growth rate, high toxicity, problematic safety and the like.

However, since these compounds except hydroquinone show effects slowly, the whitening effect is not sufficient.

Moreover, hydroquinone and kojic acid have safety problems, and hydroquinone glycoside, kojic acid and a derivative thereof, ascorbic acid and a derivative thereof, and the like have problematically high polarity for use as a cosmetic.

Furthermore, thiol compounds such as glutathione, cysteine and the like have problems in the stability after addition.

Other presently known animal and plant extracts, for example, placenta extract, aloe extract and the like show insufficient effects.

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