Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof

a technology of apparatus and liquid, applied in the field of apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof, can solve the problems of limiting the utility of higher density plates, sample volume loss, and conventional liquid handling techniques such as pipetting, piezoelectric droplet dispensing, etc., to achieve precise and known spatial location, amplification of signal, and preventing cross-contamination
US20100261159A1Inactive Publication Date: 2010-10-14LIFE TECH CORP
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
LIFE TECH CORP
Publication Date
2010-10-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Application No. 60 / 707,501, which was filed Aug. 11, 2005; and is a continuation-in-part of U.S. patent application Ser. No. 10 / 315,832, which was filed on Dec. 10, 2002, which is a divisional application of U.S. patent application Ser. No. 09 / 975,496, which was filed on Oct. 10, 2001, and is now issued as U.S. Pat. No. 6,716,629, and which claims the benefit of U.S. Provisional Application No. 60 / 239,538, filed Oct. 10, 2000, U.S. Provisional Application No. 60 / 268,894, filed Feb. 14, 2001, and U.S. Provisional Application No. 60 / 284,710, filed Apr. 18, 2001; each of the foregoing applications are hereby incorporated by reference in their entirety.FIELD OF THE INVENTION

[0002] This invention relates to devices for molecular synthesis, storage and screening, and other chemical, biochemical, biological, and physical experiments, and to methods of making, using, and manipulating the same...

Claims

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