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34 results about "1-benzofuran" patented technology
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1-Benzofuran. Other names Benzofuran Coumarone ... Benzofuran is the heterocyclic compound consisting of fused benzene and furan rings. This colourless liquid is a component of coal tar. Benzofuran is the "parent" of many related compounds with more complex structures.
Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
The present invention is directed to crystalline forms of the 5-HT2C agonist {[(2R)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride, as well as compositions, processes of preparation, and uses thereof.
![Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride](https://images-eureka.patsnap.com/patent_img/dca15bac-68e1-41f5-bf49-9420341ac2d4/US20060252825A1-20061109-D00000.png "Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride")
![Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride](https://images-eureka.patsnap.com/patent_img/dca15bac-68e1-41f5-bf49-9420341ac2d4/US20060252825A1-20061109-D00001.png "Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride")
![Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride](https://images-eureka.patsnap.com/patent_img/dca15bac-68e1-41f5-bf49-9420341ac2d4/US20060252825A1-20061109-D00002.png "Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride")
Owner:WYETH
Pharmaceutical composition
InactiveUS20100273852A1Inhibits nerve cell deathPromote regenerationBiocideNervous disorder1-benzofuranSURFACTANT BLEND
There is provided a pharmaceutical composition comprising (1) (R)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline, (2) a lipophilic component, and (3) a surfactant, which can stably and sufficiently provide improvement in the absorbability of the drug without being affected by the amount and quality of a meal.
Owner:TAKEDA PHARMA CO LTD
EVA hot melt adhesive with high bonding strength
ActiveCN110330901AHigh bonding strengthImprove cohesive strengthNon-macromolecular adhesive additivesMacromolecular adhesive additivesParaffin waxBenzoyl peroxide
The invention discloses an EVA hot melt adhesive with high bonding strength. The EVA hot melt adhesive with high bonding strength comprises the following raw materials in parts by weight: 100 parts ofEVA resin, 8-19 parts of SBS thermoplastic elastomer, 4-11 parts of hydroxyl-terminated polyurethane resin, 0.2-1.3 parts of polyacrylamide, 0.15-0.8 part of 2-vinyl-1-benzofuran, 11-15 parts of hydrogenated C5 petroleum resin, 5-13 parts of polyethylene wax, 1-3 parts of paraffin wax, 0.12-0.34 part of an antioxidant, 0.01-0.1 part of benzoyl peroxide, 0.01-0.07 part of europium acrylate and 13-28 parts of filler. The EVA hot melt adhesive with high bonding strength is high in bonding strength, good in high temperature resistance and excellent in aging resistance.
Owner:HUANGSHAN XINDECHENG GLUE IND CO LTD
Identification and characterization of hcv replicon variants with reduced susceptibility to hcv-796, and methods related thereto
InactiveUS20080182895A1Reduce sensitivityReduced and minimal and no susceptibilityBiocideMicrobiological testing/measurementHepatitis c rnaTreatment resistant
The present invention provides methods of decreasing the frequency of emergence, decreasing the level of resistance, and delaying the emergence of a treatment-resistant Hepatitis C viral infection, by administering to a subject, either in combination or in series, an inhibitor of the Hepatitis C RNA-dependent RNA polymerase NS5B, e.g., a benzofuran, such as 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide (HCV-796), and at least one additional anti-Hepatitis C agent, e.g., a ribavirin product or an immunomodulator, such as an interferon product. Additionally, the invention relates to methods of monitoring the course of treatment of a Hepatitis C viral infection, methods of monitoring and prognosing a Hepatitis C viral infection, and methods of identifying an individual with a decreased likelihood of responding to an anti-Hepatitis C viral therapy. These methods use the sequence and / or structure of the Hepatitis C RNA-dependent RNA polymerase NS5B to identify the emergence of a treatment-resistant Hepatitis C viral infection, particularly a benzofuran (e.g., HCV-796) treatment-resistant Hepatitis C viral infection.
Owner:WYETH LLC +1
Method for preparing darifenacin intermediate 5-(2-bromoethyl)-2,3-dihydro-1-benzofuran
InactiveCN101857581ASimple and fast operationRaw materials are easy to getOrganic chemistryAcetic acid1-benzofuran
The invention provides a method for preparing darifenacin intermediate 5-(2-bromoethyl)-2,3-dihydro-1-benzofuran. The method comprises the following steps of: directly reducing 2,3-dihydro benzofuran-5-acetic acid serving as a raw material into 2,3-dihydro benzofuran-5-ethanol in the presence of an ether solvent; and performing bromination on the 2,3-dihydro benzofuran-5-ethanol to obtain 5-(2-bromoethyl)-2,3-dihydro-1-benzofuran. The method has the advantages of simple and convenient operation, readily available raw material, high yield, low production cost and suitability for industrial production.
Owner:ZHEJIANG MENOVO PHARMA
EVA hot melt adhesive for book binding
InactiveCN105802547ANon-macromolecular adhesive additivesMacromolecular adhesive additivesBenzeneAntioxidant
The invention discloses EVA hot melt adhesive for book binding.The EVA hot melt adhesive is characterized by at least being prepared from, by weight, 100 parts of EVA resin, 1-7 parts of vinyl benzene fused-heterocycle mixture, 15-40 parts of tackifier, 10-20 parts of a viscosity conditioning agent, 0.01-0.5 part of antioxidant, 0.05-0.5 part of initiator and 20-50 parts of filler.The vinyl benzene fused-heterocycle mixture includes a vinyl benzene fused-heterocycle compound, a sulfonated vinyl benzene fused-heterocycle compound and an acylated benzene fused-heterocycle compound, and the vinyl benzene fused-heterocycle compound is selected from 2-vinyl-1-benzofuran or 2-vinyl-1-benzothiophene.
Owner:SHANGHAI JENTAI NANO SCI & TECH CO LTD
Use of a melatonin agonist for the treatment of sleep disorders including primary insomnia
Embodiments of the invention include the treatment of a sleep disorder comprising the administration of N-[[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cycloproply]methyl]propanamide or a salt, stereoisomer, solvate, or hydrate thereof, in amorphous or crystalline form.
Owner:VANDA PHARMA INC
Polymorphs of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsufonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and methods of making the same
Substantially pure polymorphic forms of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide are produced by recrystallization in an organic solvent.
![Polymorphs of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsufonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and methods of making the same](https://images-eureka.patsnap.com/patent_img/f15fb06f-5102-4d17-9266-539684ff24dd/US20070265335A1-20071115-D00000.png "Polymorphs of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsufonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and methods of making the same")
![Polymorphs of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsufonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and methods of making the same](https://images-eureka.patsnap.com/patent_img/f15fb06f-5102-4d17-9266-539684ff24dd/US20070265335A1-20071115-D00001.png "Polymorphs of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsufonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and methods of making the same")
![Polymorphs of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsufonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and methods of making the same](https://images-eureka.patsnap.com/patent_img/f15fb06f-5102-4d17-9266-539684ff24dd/US20070265335A1-20071115-D00002.png "Polymorphs of 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsufonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and methods of making the same")
Owner:WYETH LLC +1
Preparation process of benzofuran
InactiveCN102653529AReaction raw materials are cheap and easy to obtainShort reaction timeOrganic chemistryKetone1-benzofuran
The invention relates to the field of medical intermediate synthesis, in particular to a process route for synthesizing an important medical intermediate benzofuran. The process route for synthesizing benzofuran mainly comprises the following step of: reacting substituted o-hydroxybenzaldehyde, o-hydroxyphenyl alkyl ketone, or o-hydroxybenzonitrile with 2-halogenated aliphatic acid or the corresponding ester under the action of alkali to obtain the corresponding substituted benzofuran. The invention provides a method for preparing benzofuran, which is simple and can realize industrialized production; and the process route provided by the invention has the characteristics of economy, rapidness, environmental friendliness, high yield and the like.
Owner:GUANGDONG MEDICAL UNIV
Medical uses of methyl (E)-3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]-prop-2-enoate
InactiveCN103417527APrevent proliferationAntitumor effect is obviousOrganic active ingredientsMicrobiological testing/measurementChemical industrySide effect
The invention belongs to the fields of chemical industry and medicine, and relates to medical uses of methyl (E)-3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]-prop-2-enoate (hereafter referred to as H4 for short). The invention provides applications of H4 in preparation of antitumor drugs and a corresponding antitumor drug composition. The invention also provides a method for inhibiting tumor cell proliferation in vitro. According to the method, the H4 is added into nutrient solution of tumor cells, which include hepatoma cells, gastric cancer cells, or leukemia cells. The H4 is a natural product with small toxic side effects, high bioavailability and stable properties, and thus is valuable for clinical use. The small molecule provided by the invention is developed as a novel antitumor drug or an auxiliary component thereof, has a significant antitumor effect, and is environmentally friendly.
![Medical uses of methyl (E)-3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]-prop-2-enoate](https://images-eureka.patsnap.com/patent_img/2ef540fa-2a58-42da-a03e-a683c5aae0f6/BDA00001665137700011.PNG "Medical uses of methyl (E)-3-[2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]-prop-2-enoate")
Owner:FUDAN UNIV
Aminoindan derivative or salt thereof
InactiveCN101489984AHas NMDA receptor antagonistic effectPrevent Alzheimer's DiseaseNervous disorderOrganic chemistryDiseaseFuran
Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, or pain. A novel compound or a salt thereof, which is characterized in that it has an amino group and R1 (lower alkyl, cycloalkyl, -lower alkylene-aryl, aryl which may be substituted, and the like) on carbon atoms of indane, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine, or cyclopenta[c]pyridine ring, or 2, 3-dihydrdo-1-benzofuran, 2, 3-dihydrdo-1-benzothiophene, indoline ring, or the like, and has R2 and R3 (the same or different, each lower alkyl or aryl) on carbon atoms beside them, and an NMDA receptor antagonist comprising the same as an active component.
Owner:ASTELLAS PHARMA INC
Aminoindane derivative or salt thereof
Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, or pain.A novel compound or a salt thereof, which is characterized in that it has an amino group and R1 (lower alkyl, cycloalkyl, -lower alkylene-aryl, aryl which may be substituted, and the like) on carbon atoms of indane, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine, or cyclopenta[c]pyridine ring, or 2,3-dihydrdo-1-benzofuran, 2,3-dihydrdo-1-benzothiophene, indoline ring, or the like, and has R2 and R3 (the same or different, each lower alkyl or aryl) on carbon atoms beside them, and an NMDA receptor antagonist comprising the same as an active component.
Owner:ASTELLAS PHARMA INC
Treatment agent for removing sulfide from oil-fired boiler tail gas
InactiveCN105233652AStrong complexing abilityFast precipitationDispersed particle separationStyrene oxidePyridazine
The invention relates to a treatment agent for removing sulfide from oil-fired boiler tail gas. The treatment agent is prepared by compounding of the following components: 5, 7-trihydroxy-2- (3, 4, 5-trihydroxyphenyl)-4H-1-benzofuran-4-one, harringtonine, 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one, pentahydroxyflavone-3-rhamnoside, 3-methyl pyridazine, 4-acetoxy-3-methoxy-(2-allyl)benzene, 4, 4'-sulfonyldianiline, and 3-methyl-3-phenyloxiranecarboxylic acid ethyl ester, 5-allyl-2, 3-(methylenedioxy)anisole, etc. The treatment agent has strong complexing ability with a target material, the complex precipitate forming rate is fast, the removal rate can reach 99%, the cost is low, the dosage is small, scaling does not form, and the treatment agent does not cause environmental harm.
Owner:李宇花
Long-lasting, high-humidity and mold-proof silicone sealant
ActiveCN106010392AImprove mildew resistanceEasy to prepareNon-macromolecular adhesive additivesGraft polymer adhesivesDrying timePolymer chemistry
The invention relates to a sealing material, in particular to long-lasting, high-humidity and mold-proof silicone sealant. The long-lasting, high-humidity, mold-proof silicone sealant is prepared from the following raw materials: alpha-hydro-omega-hydroxy-polydimethylsiloxane, 6-(beta-D-glucopyranosyl-oxy)-7-hydroxy-2H-1-benzofuran-2-one, (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)methyl (1R-trans)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate, trimethyl[(1-methyl-ethenyl)oxy]-silane, 2-ethylhexyl 4-methoxycinnamate, and the like. The long-lasting, high-humidity and mold-proof silicone sealant is good in mold-proof performance, relatively long in storage time, simple in preparation method, relatively short in surface drying time, shortened in work time, improved in work efficiency, and free of yellowing, and is suitable for promotion and application in the field of mold-proof silicone sealant.
Owner:安徽斯迈特新材料股份有限公司
EVA hot-melt adhesive for refrigerator sealing
InactiveCN105860880ANon-macromolecular adhesive additivesMacromolecular adhesive additivesBenzothiopheneTackifier
The invention discloses an EVA hot-melt adhesive for refrigerator sealing. The EVA hot-melt adhesive for refrigerator sealing is prepared from, by weight, 100 parts of EVA resin, 1-4 parts of a vinyl fused ring mixture, 30-50 parts of a tackifier, 10-15 parts of a viscosity modifier, 0.2-1 part of an antioxidant, 0.1-0.5 part of an initiator and 20-30 parts of filler, wherein the vinyl fused ring mixture is prepared from an acylated vinyl fused ring compound and a non-acylated vinyl fused ring compound, and the vinyl fused ring compounds are selected from 2-vinyl-1-benzofuran and 2-vinyl-1-benzothiophene.
Owner:SHANGHAI JENTAI NANO SCI & TECH CO LTD
Pharmaceutical formulations containing 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and method of making the same
Pharmaceutical formulations containing 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide and pharmaceutically acceptable additives including at least one surfactant are made.
![Pharmaceutical formulations containing 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and method of making the same](https://images-eureka.patsnap.com/patent_img/bb7b096f-cc4d-4ab2-b315-af8fd52979a2/US20070128270A1-20070607-D00001.png "Pharmaceutical formulations containing 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and method of making the same")
![Pharmaceutical formulations containing 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and method of making the same](https://images-eureka.patsnap.com/patent_img/bb7b096f-cc4d-4ab2-b315-af8fd52979a2/US20070128270A1-20070607-D00002.png "Pharmaceutical formulations containing 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and method of making the same")
![Pharmaceutical formulations containing 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and method of making the same](https://images-eureka.patsnap.com/patent_img/bb7b096f-cc4d-4ab2-b315-af8fd52979a2/US20070128270A1-20070607-C00001.png "Pharmaceutical formulations containing 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-n-methyl-1-benzofuran-3-carboxamide and method of making the same")
Owner:VIROPHARMA INC
EVA hot-melt adhesive for kitchenware
InactiveCN105860879ANon-macromolecular adhesive additivesMacromolecular adhesive additivesAntioxidantBenzothiophene
The invention discloses an EVA hot-melt adhesive for kitchenware. The EVA hot-melt adhesive for kitchenware is at least prepared from, by weight, 100 parts of EVA resin, 0.1-10 parts of a vinylbenzene fused heterocycle mixture, 15-40 parts of a tackifier, 10-20 parts of a viscosity modifier, 0.01-0.5 part of an antioxidant, 0.05-0.5 part of an initiator and 20-50 parts of filler, wherein the vinylbenzene fused heterocycle mixture is prepared from a sulfonated vinylbenzene fused heterocycle compound and a non-sulfonated vinylbenzene fused heterocycle compound, and the vinylbenzene fused heterocycle compounds are selected from 2-vinyl-1-benzofuran and 2-vinyl-1-benzothiophene.
Owner:SHANGHAI JENTAI NANO SCI & TECH CO LTD
EVA hot melt adhesive for storage battery
InactiveCN105778827ANon-macromolecular adhesive additivesMacromolecular adhesive additivesAntioxidantBenzothiophene
An EVA hot melt adhesive for a storage battery is at least prepared from, by weight, 100 parts of EVA resin, 5-10 parts of a vinyl condensed ring mixture, 2-5 parts of alpha-olefin containing an aromatic ring substituent group, 20-40 parts of tackifier, 12-18 parts of a viscosity modifier, 0.01-0.5 part of an antioxidant, 0.05-0.2 part of an initiating agent and 30-40 parts of packing, wherein the vinyl condensed ring mixture comprises an acylated vinyl condensed ring compound and an non-acylated vinyl condensed ring compound, the vinyl condensed ring compound is selected from 2-vinyl-1-benzofuran or 2-vinyl-1-benzothiophene, and the aromatic ring substituent group contains elemental sulphur.
Owner:SHANGHAI JENTAI NANO SCI & TECH CO LTD
eva hot melt adhesive for book binding
InactiveCN105802547BNon-macromolecular adhesive additivesMacromolecular adhesive additivesBenzeneAntioxidant
Owner:SHANGHAI JENTAI NANO SCI & TECH CO LTD
eva hot melt adhesive for refrigerator sealing
InactiveCN105860880BNon-macromolecular adhesive additivesMacromolecular adhesive additivesAntioxidantBenzothiophene
The invention discloses an EVA hot-melt adhesive for refrigerator sealing. The EVA hot-melt adhesive for refrigerator sealing is prepared from, by weight, 100 parts of EVA resin, 1-4 parts of a vinyl fused ring mixture, 30-50 parts of a tackifier, 10-15 parts of a viscosity modifier, 0.2-1 part of an antioxidant, 0.1-0.5 part of an initiator and 20-30 parts of filler, wherein the vinyl fused ring mixture is prepared from an acylated vinyl fused ring compound and a non-acylated vinyl fused ring compound, and the vinyl fused ring compounds are selected from 2-vinyl-1-benzofuran and 2-vinyl-1-benzothiophene.
Owner:SHANGHAI JENTAI NANO SCI & TECH CO LTD
Synthesis method of 2,3-dihydro-1-benzofuran-4-carbaldehyde
ActiveCN106588841AMild reaction conditionsSuitable for large-scale industrial applicationsOrganic chemistryMetalloleSynthesis methods
The invention relates to a synthesis method of 2,3-dihydro-1-benzofuran-4-carbaldehyde. The formula of 2,3-dihydro-1-benzofuran-4-carbaldehyde can be shown in the formula (I). The synthesis method comprises the steps of making a compound shown in the formula (II) be subjected to intramolecular cyclization reaction so as to produce a compound shown in the formula (III) under the existence of alkali metal compounds and Cu(1); making the compound shown in the formula (III) be subjected to reaction together with magnesium and a compound shown in the formula R3CONR1R2(IV) so as to obtain the compound shown in the formula (I). According to the synthesis method of 2,3-dihydro-1-benzofuran-4-carbaldehyde, reaction conditions are mild, procedures are simple, byproducts are few, and thus the synthesis method of 2,3-dihydro-1-benzofuran-4-carbaldehyde is suitable for being applied to large scale industrial production.
Owner:富乐马鸿凯(大连)医药有限公司
Process for the preparation of dronedarone
This invention relates to a process for the preparation of N-[2-n-butyl-3-{4-[(3- dibutylamino)-propoxy]-benzoyl} - 1-benzofuran-5-yl]-methane-sulfonamide of formula (I) and its pharmaceutically acceptable salts, according to one of the methylsulfonyl groups of the 2-n-butyl-3-[(di-n-butylamino-3-propoxy)-benzoyl]-5- bis-(methylsulfonamido)-benzofuran of formula (II) is selectively cleaved and if desired, the resulting compound of formula (I) is transformed into its salt.
Owner:SANOFI SA
Aminoindane derivative or salt thereof
Provided is a compound that is an NMDA receptor antagonist having a broader safety margin, and is useful as an agent for treating or preventing Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, or pain.A novel compound or a salt thereof, which is characterized in that it has an amino group and R1 (lower alkyl, cycloalkyl, -lower alkylene-aryl, aryl which may be substituted, and the like) on carbon atoms of indane, cyclopenta[b]thiophene, cyclopenta[b]furan, cyclopenta[b]pyridine, or cyclopenta[c]pyridine ring, or 2,3 -dihydro-1-benzofuran, 2,3-dihydro-1-benzothiophene, indoline ring, or the like, and has R2 and R3 (the same or different, each lower alkyl or aryl) on carbon atoms beside them, and an NMDA receptor antagonist comprising the same as an active component.
Owner:ASTELLAS PHARMA INC
A long-lasting high-humidity mildew-proof silicone sealant
ActiveCN106010392BImprove mildew resistanceEasy to prepareNon-macromolecular adhesive additivesGraft polymer adhesivesHigh humiditySilanes
The invention relates to a sealing material, in particular to long-lasting, high-humidity and mold-proof silicone sealant. The long-lasting, high-humidity, mold-proof silicone sealant is prepared from the following raw materials: alpha-hydro-omega-hydroxy-polydimethylsiloxane, 6-(beta-D-glucopyranosyl-oxy)-7-hydroxy-2H-1-benzofuran-2-one, (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)methyl (1R-trans)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate, trimethyl[(1-methyl-ethenyl)oxy]-silane, 2-ethylhexyl 4-methoxycinnamate, and the like. The long-lasting, high-humidity and mold-proof silicone sealant is good in mold-proof performance, relatively long in storage time, simple in preparation method, relatively short in surface drying time, shortened in work time, improved in work efficiency, and free of yellowing, and is suitable for promotion and application in the field of mold-proof silicone sealant.
Owner:安徽斯迈特新材料股份有限公司
eva hot melt adhesive for kitchenware
InactiveCN105860879BNon-macromolecular adhesive additivesMacromolecular adhesive additivesKitchen utensilsBenzothiophene
The invention discloses an EVA hot-melt adhesive for kitchenware. The EVA hot-melt adhesive for kitchenware is at least prepared from, by weight, 100 parts of EVA resin, 0.1-10 parts of a vinylbenzene fused heterocycle mixture, 15-40 parts of a tackifier, 10-20 parts of a viscosity modifier, 0.01-0.5 part of an antioxidant, 0.05-0.5 part of an initiator and 20-50 parts of filler, wherein the vinylbenzene fused heterocycle mixture is prepared from a sulfonated vinylbenzene fused heterocycle compound and a non-sulfonated vinylbenzene fused heterocycle compound, and the vinylbenzene fused heterocycle compounds are selected from 2-vinyl-1-benzofuran and 2-vinyl-1-benzothiophene.
Owner:SHANGHAI JENTAI NANO SCI & TECH CO LTD
Method for removing sulfide in oil burning boiler tail gas
InactiveCN105289244AStrong complexing abilityFast precipitationDispersed particle separationBenzenePentahydroxyflavone
The invention relates to a method for removing sulfide in oil burning boiler tail gas. The method includes the step that the oil burning boiler tail gas is introduced into enough desulfurizer through a pipeline, and sulfur dioxide, sulfur trioxide and hydrogen sulfide in the tail gas react with the desulfurizer to form complex precipitates to be filtered out. The desulfurizer is prepared from, by weight, 5,7-trihydroxy-2-(3,4,5-trihydroxy phenyl)-4H-1-benzofuran-4-ketone, harringtonin, 7-hydroxy-6-methoxy-2H-1-benzofuran-2-ketone, pentahydroxy flavone-3-rhamnoside, 3-methyl pyridazine, 4-acetoxyl-3-methoxy-(2-propenyl) benzene, 4,4'-sulfonyldiphenylamine and the like. According to the treatment method, the capacity of complexing the target substances is high, the speed of forming the complex precipitates is high, the removal rate can reach 99%, cost is low, usage amount is small, scale formation is avoided, and the environment is not damaged.
Owner:李宇花
Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
The present invention is directed to crystalline forms of the 5-HT2C agonist {[(2R)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride, as well as compositions, processes of preparation, and uses thereof.
![Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride](https://images-eureka.patsnap.com/patent_img/713e16cb-30ca-468e-81e6-9bc88f00989f/S2006800134372E00011.PNG "Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride")
![Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride](https://images-eureka.patsnap.com/patent_img/713e16cb-30ca-468e-81e6-9bc88f00989f/S2006800134372E00021.PNG "Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride")
![Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride](https://images-eureka.patsnap.com/patent_img/713e16cb-30ca-468e-81e6-9bc88f00989f/S2006800134372E00031.PNG "Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride")
Owner:WYETH LLC
Process for preparation of dronedarone by mesylation
The invention relates to a novel process for preparation of N-[2-n-butyl-3-[4-[3-(di-n-butylamino)-propoxy]-benzoyl]-benzofuran-5-yl]methanesulfonamide (I) and pharmaceutical acceptable salts thereof, where a salt of (5-amino-2-butyl-1-benzofuran-3-yl){4-[3-(di-n-butylamino)propoxy]phenyl}methanone of formula (II)—where A is a mono- or dibasic acid forming an acid addition salt with the compound of formula (II), n is 1 if A is dibasic acid and n is 1 or 2 if A is a monobasic acid—is reacted with a mesylating reagent in a heterogen reaction, if desired, in the presence of a phase transfer catalyst. The invention also relates to the novel salts of compound of formula (II), for the preparation thereof and their use in the preparation of dronedarone.
Owner:SANOFI SA
Method for synthesizing 2,3-dihydro-1-benzofuran-4-carbaldehyde
ActiveCN106588841BImprove efficiencySuitable for large-scale industrial productionOrganic chemistryMetalloleSynthesis methods
The invention relates to a synthesis method of 2,3-dihydro-1-benzofuran-4-carbaldehyde. The formula of 2,3-dihydro-1-benzofuran-4-carbaldehyde can be shown in the formula (I). The synthesis method comprises the steps of making a compound shown in the formula (II) be subjected to intramolecular cyclization reaction so as to produce a compound shown in the formula (III) under the existence of alkali metal compounds and Cu(1); making the compound shown in the formula (III) be subjected to reaction together with magnesium and a compound shown in the formula R3CONR1R2(IV) so as to obtain the compound shown in the formula (I). According to the synthesis method of 2,3-dihydro-1-benzofuran-4-carbaldehyde, reaction conditions are mild, procedures are simple, byproducts are few, and thus the synthesis method of 2,3-dihydro-1-benzofuran-4-carbaldehyde is suitable for being applied to large scale industrial production.
Owner:富乐马鸿凯(大连)医药有限公司
eva hot melt adhesive for storage battery
InactiveCN105778827BNon-macromolecular adhesive additivesMacromolecular adhesive additivesAntioxidantBenzothiophene
Owner:SHANGHAI JENTAI NANO SCI & TECH CO LTD
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