The invention relates to a sealing material, in particular to long-lasting, high-humidity and mold-proof silicone sealant. The long-lasting, high-humidity, mold-proof silicone sealant is prepared from the following raw materials: alpha-hydro-omega-hydroxy-polydimethylsiloxane, 6-(beta-D-glucopyranosyl-oxy)-7-hydroxy-2H-1-benzofuran-2-one, (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)methyl (1R-trans)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate, trimethyl[(1-methyl-ethenyl)oxy]-silane, 2-ethylhexyl 4-methoxycinnamate, and the like. The long-lasting, high-humidity and mold-proof silicone sealant is good in mold-proof performance, relatively long in storage time, simple in preparation method, relatively short in surface drying time, shortened in work time, improved in work efficiency, and free of yellowing, and is suitable for promotion and application in the field of mold-proof silicone sealant.