32 results about "Fluid responsiveness" patented technology

A hemodynamic monitor and corresponding method for determining the requirement for, and if required the nature or extent of, and for monitoring the response to, an intervention by a carer for a subject in order to improve the hydration level and hemodynamic status of the subject during a period or periods of hemodynamic instability includes, firstly, a processor. The processor incorporates software arranged to continuously analyse and process a blood pressure or arterial volume / plethysmographic signal obtained from the subject in order to derive a plurality of complementary parameters throughout the monitoring of the subject. The monitor also incorporates display means displaying images representing the derived plurality of complementary parameters. The images may include at least one image representing graphically at least one stress related hemodynamic parameter plotted against time to provide an immediate indication of a change in hemodynamic status and thus the requirement for an intervention. The images may also include at least one image representing graphically at least one fluid responsiveness parameter plotted against time to provide an indication of the hydration level and associated ventricular pre load status of the subject to determine the nature or extent of the intervention if required. Respiratory variations in fluid responsiveness parameters may usefully be displayed. The images may also include at least one image representing graphically at least one response related parameter compared to the value of the parameter at the point of the intervention to provide an indication of the desired and / or actual response of the subject to an intervention. Trend and acute changes displays may be combined. Specific parameters providing information on the quality of the left ventricle and right heart / venous return / preload may also be derived and displayed.

An extravascular system includes a catheter assembly, a needle assembly, and a hemostatic adapter. The catheter assembly defines a lumen extending from a distal end thereof to a catheter hub at a proximal end thereof. The needle assembly includes a needle hub disposed at a proximal end of a needle disposed within the lumen defined by the catheter assembly. The hemostatic adapter defines a passage and is adapted to be operatively associated with the needle assembly and the catheter assembly. The hemostatic adapter-further includes at least one liquid-reactive material adapted to at least substantially seal the passage. The liquid-reactive material is selected and configured to morph upon contact with liquids to provide a mechanical barrier to prevent blood flow. A fluid may be injected into the lumen and / or passage by way of an optional port to provide a fluidic barrier in addition to the mechanical barrier.

A bulk, generally elastomeric and pliable, layered mat formed to permit selective trimming into size-chosen mat trims / tiles, each of which is structured to perform as a self-puncture(wound)-sealing, defined-liquid-reactive, anti-puncture-leakage coating element applicable bondedly to the outside surface of a selected wall in a container holding the defined-liquid. Also disclosed is a method for protecting against liquid leakage from a puncture wound in such a wall including: (a) preparing a generally elastomeric, pliable, layered coating mat of a self-puncture-healing, defined-liquid-reactive, anti-puncture-leakage material; (b) in relation to a selected container wall, selectively removing, by trimming, from the prepared mat one or more mat trims / tiles shaped for specific use on the outside surface of that wall; and (c) applying and surface-bonding the one or more trims / tiles to the outside surface of the selected wall.

The present invention discloses a method and related apparatus for determining a cardiac parameter from either the arterial blood pressure signal or the photoplethysmographic signal to quantify the degree of amplitude modulation due to respiration (pulse pressure variation) and predict fluid responsiveness. The method involves the application of Lempel-Ziv complexity to a filtered and segmented physiologic signal for direct determination of the fluid status of a patient. Real-time monitoring of fluid status involves the implementation of the disclosed method as part of a bedside monitoring apparatus.

Composite gear blanks are manufactured by placing a rigid centerpiece in a mold, optionally inertizing the mold, filling the mold by adding a liquid reactive mixture around the centerpiece, applying static pressure to the mold and polymerizing the reactive mixture so as to form a plastic outer part surrounding the centerpiece. The composite gear blanks thus made have improved values of normal and shear adhesion strength both at room temperature and at elevated temperatures of up to 120° C. and are particularly suited for making worm gear parts of automotive electronic power steering systems.

We have devised an apparatus useful for and a method of removing impurities from vaporous precursor compositions used to generate reactive precursor vapors from which thin films / layers are formed under sub-atmospheric conditions. The method is particularly useful when the layer deposition apparatus provides for precise addition of quantities of different combinations of reactants during a single step or when there are a number of different individual steps in the layer formation process, where the presence of impurities has a significant affect on both the quantity of reactants being charged and the overall composition of the reactant mixture from which the layer is deposited. The method is particularly useful when the vapor pressure of a liquid reactive precursor is less than about 250 Torr at atmospheric pressure.

A hemodynamic monitor including a processor incorporating software arranged to continuously analyze and process a blood pressure or arterial volume / plethysmographic signal obtained from the subject in order to derive a plurality of complementary parameters throughout the monitoring of the subject. The monitor also incorporates a display arranged to interact with the processor to display images representing the derived plurality of complementary parameters. The images include at least one image representing graphically at least one stress related hemodynamic parameter plotted against time and at least one image representing graphically at least one fluid responsiveness parameter plotted against time.

A method of manufacturing a composite insert includes forming a polymer mold from a polymer sheet which may have a glass transition temperature of 70 to 160° C., the polymer mold either includes a cavity or may form a cavity disposed between the polymer mold and the carrier. The method proceeds by depositing a liquid reactive composite insert composition, which may be a two-component composition including a first part comprised of an isocyanate-epoxy blend and a second part comprised of an alcohol-epoxy blend, into the cavity under low pressure conditions of 0-10 bar and low temperature conditions of 15-100° C. The composition is then allowed to become dimensionally stable either within the polymer mold or between the polymer mold and the carrier.

Methods for determining a cardiovascular parameter reflecting fluid or volume changes and for detecting arrhythmia are disclosed. These methods involve receiving a waveform dataset corresponding to an arterial blood pressure, pulseox, Doppler ultrasound or bioimpedance signal and analyzing the waveform to detect premature ventrical or atrial contractions. Premature ventrical or atrial contractions are detected, for example, by comparing parameters of individual cardiac cycles to the parameters of other or average cardiac cycles. If any premature ventrical or atrial contractions are present, they are removed from the waveform dataset. Once any the premature ventrical or atrial contractions are removed, a cardiovascular parameter reflecting fluid or volume changes using the modified waveform dataset is calculated. In the method for determining arrhythmia, if the number of premature ventrical or atrial contractions exceeds a predetermined arrhythmia threshold, a user such as a medical professional is notified.

A system (100) for assessing fluid responsiveness comprising: an infusion pump (24) in communication with at least one processor (32); and a plurality of physiological monitors (40, 42, 44, 46), It can be used to receive physiological signals from an associated patient. synchronizing physiological signals (48, 50) acquired from said associated patient (10) during a solution burst with a timing signal (54) of said infusion pump (24) administering said solution burst, according to One or more dynamic indicators and / or features (58) are calculated from the synchronized physiological signals (50) and based on the baseline physiological signals (48) collected from the associated patient (10) prior to administration of the solution burst to calculate one or more dynamic indicators and / or characteristics (50), based on the dynamic indicators and / or characteristics (58) from the synchronized physiological signal (50) and from the baseline physiological signal (48) The fluid responsiveness probability value (64) of said patient (10) is determined by the dynamic indication and / or characteristic (50) of said patient (10).

A technique for predicting fluid responsiveness in a critically ill patient comprises measuring physiological data of the patient, then generating an estimate of pulse pressure variability from a Fourier transform of the physiological waveform. Both invasive and non-invasive physiological data measurements may be used.