32 results about "Fluid responsiveness" patented technology

A method of preparing fiber reinforced acrylic thickened compositions which can be molded under low pressures and temperatures to provide thermoset articles, wherein liquid reactive components are slowly absorbed in high molecular weight solid acrylic resin in the form of large particles. The acrylic resin functions as a thickener which delays the viscosity build allowing fiber reinforcement to be incorporated before molding. The molding composition is well suited for use in dentistry and other fields where small amounts or molding composition are used occasionally.

A hemodynamic monitor and corresponding method for determining the requirement for, and if required the nature or extent of, and for monitoring the response to, an intervention by a carer for a subject in order to improve the hydration level and hemodynamic status of the subject during a period or periods of hemodynamic instability includes, firstly, a processor. The processor incorporates software arranged to continuously analyse and process a blood pressure or arterial volume / plethysmographic signal obtained from the subject in order to derive a plurality of complementary parameters throughout the monitoring of the subject. The monitor also incorporates display means displaying images representing the derived plurality of complementary parameters. The images may include at least one image representing graphically at least one stress related hemodynamic parameter plotted against time to provide an immediate indication of a change in hemodynamic status and thus the requirement for an intervention. The images may also include at least one image representing graphically at least one fluid responsiveness parameter plotted against time to provide an indication of the hydration level and associated ventricular pre load status of the subject to determine the nature or extent of the intervention if required. Respiratory variations in fluid responsiveness parameters may usefully be displayed. The images may also include at least one image representing graphically at least one response related parameter compared to the value of the parameter at the point of the intervention to provide an indication of the desired and / or actual response of the subject to an intervention. Trend and acute changes displays may be combined. Specific parameters providing information on the quality of the left ventricle and right heart / venous return / preload may also be derived and displayed.

An extravascular system includes a catheter assembly, a needle assembly, and a hemostatic adapter. The catheter assembly defines a lumen extending from a distal end thereof to a catheter hub at a proximal end thereof. The needle assembly includes a needle hub disposed at a proximal end of a needle disposed within the lumen defined by the catheter assembly. The hemostatic adapter defines a passage and is adapted to be operatively associated with the needle assembly and the catheter assembly. The hemostatic adapter-further includes at least one liquid-reactive material adapted to at least substantially seal the passage. The liquid-reactive material is selected and configured to morph upon contact with liquids to provide a mechanical barrier to prevent blood flow. A fluid may be injected into the lumen and / or passage by way of an optional port to provide a fluidic barrier in addition to the mechanical barrier.

A bulk, generally elastomeric and pliable, layered mat formed to permit selective trimming into size-chosen mat trims / tiles, each of which is structured to perform as a self-puncture(wound)-sealing, defined-liquid-reactive, anti-puncture-leakage coating element applicable bondedly to the outside surface of a selected wall in a container holding the defined-liquid. Also disclosed is a method for protecting against liquid leakage from a puncture wound in such a wall including: (a) preparing a generally elastomeric, pliable, layered coating mat of a self-puncture-healing, defined-liquid-reactive, anti-puncture-leakage material; (b) in relation to a selected container wall, selectively removing, by trimming, from the prepared mat one or more mat trims / tiles shaped for specific use on the outside surface of that wall; and (c) applying and surface-bonding the one or more trims / tiles to the outside surface of the selected wall.

The present invention discloses a method and related apparatus for determining a cardiac parameter from either the arterial blood pressure signal or the photoplethysmographic signal to quantify the degree of amplitude modulation due to respiration (pulse pressure variation) and predict fluid responsiveness. The method involves the application of Lempel-Ziv complexity to a filtered and segmented physiologic signal for direct determination of the fluid status of a patient. Real-time monitoring of fluid status involves the implementation of the disclosed method as part of a bedside monitoring apparatus.

An extravascular system includes a catheter assembly, a needle assembly, and a hemostatic adapter. The catheter assembly defines a lumen extending from an opening at a distal end thereof to a catheter hub at a proximal end thereof. The needle assembly includes a needle hub disposed at a proximal end of a needle disposed within the lumen defined by the catheter assembly. The needle has a needle tip extending from the opening of the catheter assembly. The hemostatic adapter defines a passage and is adapted to be operatively associated with the needle assembly and the catheter assembly. The hemostatic adapter further includes at least one liquid-reactive material adapted to at least substantially seal the passage upon contact with one or more liquids. The liquid-reactive material is selected and configured to morph upon contact with liquids to provide a mechanical barrier to prevent blood flow. A fluid may be injected into the lumen and / or passage by way of an optional port to provide a fluidic barrier in addition to the mechanical barrier.

We have devised an apparatus useful for and a method of removing impurities from vaporous precursor compositions used to generate reactive precursor vapors from which thin films / layers are formed under sub-atmospheric conditions. The method is particularly useful when the layer deposition apparatus provides for precise addition of quantities of different combinations of reactants during a single step or when there are a number of different individual steps in the layer formation process, where the presence of impurities has a significant affect on both the quantity of reactants being charged and the overall composition of the reactant mixture from which the layer is deposited. The method is particularly useful when the vapor pressure of a liquid reactive precursor is less than about 250 Torr at atmospheric pressure.

A method of preparing fiber sheet molding compounds with a fabric of continuous fiber reinforcement that can be molded under low pressures and temperatures to provide thermoset articles, wherein liquid reactive components are slowly absorbed in solid acrylic resin. The acrylic resin functions as a thickener which delays the viscosity build allowing the fabric of continuous fiber reinforcement to be incorporated before molding.

A system is provided including a ventilator detection module, a circulatory detection module, and an analysis module. The ventilator detection module is configured to detect ventilator information representative of a ventilation activity. The circulatory detection module is configured to detect circulatory information representative of the circulation of the patient. The analysis module is configured to obtain a ventilator waveform based at least in part on the ventilator information, obtain a circulatory waveform based at least in part on the circulatory information, combine the ventilator waveform and the circulatory waveform to provide a mixed waveform, and isolate a portion of the mixed waveform to identify a ventilator responsiveness waveform representative of an effect of the ventilator.

The present invention discloses a method and related apparatus for determining a cardiac parameter from either the arterial blood pressure signal or the photoplethysmographic signal to quantify the degree of amplitude modulation due to respiration (pulse pressure variation) and predict fluid responsiveness. The method involves the application of Lempel-Ziv complexity to a filtered and segmented physiologic signal for direct determination of the fluid status of a patient. Real-time monitoring of fluid status involves the implementation of the disclosed method as part of a bedside monitoring apparatus.

Composite gear blanks are manufactured by placing a rigid centerpiece in a mold, optionally inertizing the mold, filling the mold by adding a liquid reactive mixture around the centerpiece, applying static pressure to the mold and polymerizing the reactive mixture so as to form a plastic outer part surrounding the centerpiece. The composite gear blanks thus made have improved values of normal and shear adhesion strength both at room temperature and at elevated temperatures of up to 120° C. and are particularly suited for making worm gear parts of automotive electronic power steering systems.

Embodiments provide systems and methods for displaying a fluid responsiveness predictor (FRP) based on an analysis a physiological signal detected by a physiological sensor applied to a patient. A method may include detecting the signal of the patient with the physiological sensor, determining an FRP with a FRP determination module, wherein the determining operation comprises analyzing at least one characteristic of the physiological signal over time to determine the FRP, receiving a report request to report the FRP at a requested time through a user interface, generating a reported FRP in relation to the requested time using the FRP determination module, and displaying the reported FRP on a display. The displaying operation may include displaying the FRP using at least one graphic representation.

We have devised an apparatus useful for and a method of removing impurities from vaporous precursor compositions used to generate reactive precursor vapors from which thin films / layers are formed under sub-atmospheric conditions. The method is particularly useful when the layer deposition apparatus provides for precise addition of quantities of different combinations of reactants during a single step or when there are a number of different individual steps in the layer formation process, where the presence of impurities has a significant affect on both the quantity of reactants being charged and the overall composition of the reactant mixture from which the layer is deposited. The method is particularly useful when the vapor pressure of a liquid reactive precursor is less than about 250 Torr at atmospheric pressure.

A hemodynamic monitor including a processor incorporating software arranged to continuously analyze and process a blood pressure or arterial volume / plethysmographic signal obtained from the subject in order to derive a plurality of complementary parameters throughout the monitoring of the subject. The monitor also incorporates a display arranged to interact with the processor to display images representing the derived plurality of complementary parameters. The images include at least one image representing graphically at least one stress related hemodynamic parameter plotted against time and at least one image representing graphically at least one fluid responsiveness parameter plotted against time.

Methods for determining a cardiovascular parameter reflecting fluid or volume changes and for detecting arrhythmia are disclosed. These methods involve receiving a waveform dataset corresponding to an arterial blood pressure, pulseox, Doppler ultrasound or bioimpedance signal and analyzing the waveform to detect premature ventrical or atrial contractions. Premature ventrical or atrial contractions are detected, for example, by comparing parameters of individual cardiac cycles to the parameters of other or average cardiac cycles. If any premature ventrical or atrial contractions are present, they are removed from the waveform dataset. Once any the premature ventrical or atrial contractions are removed, a cardiovascular parameter reflecting fluid or volume changes using the modified waveform dataset is calculated. In the method for determining arrhythmia, if the number of premature ventrical or atrial contractions exceeds a predetermined arrhythmia threshold, a user such as a medical professional is notified.

It is an object of the present invention to provide a gas generating device that can initiate the reaction of a liquid-reactive chemical at a specified time, and stop the supply of the reaction liquid at a specified time, so that generation of a gas by the liquid-reactive chemical can be promoted after workers have finished loading fruits, vegetables, or other produce into a treatment chamber, and a personnel-free sealed state has been formed in the treatment chamber. A gas generating device having an upper tubular part that forms a receiving chamber 3 for a reaction liquid 2 and a lower tubular part that forms a receiving chamber 5 for a liquid-reactive chemical 4, wherein a reaction liquid supply port that supplies the reaction liquid 2 inside the receiving chamber 3 to the receiving chamber 5 is provided between the receiving chambers 3 and 5; and a shut-off valve 7 is provided which opens the supply port 6 and allows the supply of the reaction liquid 2, and closes the supply port 6 and cuts off the supply of the reaction liquid 2. The device further has a gas discharge opening 9 that discharges a gas G generated inside the receiving chamber 5 to the outside from this receiving chamber 5, and further has timer means for setting the supply time of the reaction liquid via the opening and closing of the shut-off valve 7.

A bromine-containing, hydroxy-functional copolymer is prepared from an initiator that is solid at room temperature and has at least one bromine atom. The initiator is reacted with an effective amount of lactone monomers, optionally in the presence of a catalyst, to establish a bromine-containing, hydroxy-functional copolymer that is a liquid at room temperature. The copolymer of this invention may be used as liquid reactive flame retardant and, in the event the copolymer is polyfunctional, as a crosslinker.

A bulk, generally elastomeric and pliable, layered mat formed to permit selective trimming into size-chosen mat trims / tiles, each of which is structured to perform as a self-puncture(wound)-sealing, defined-liquid-reactive, anti-puncture-leakage coating element applicable bondedly to the outside surface of a selected wall in a container holding the defined-liquid. Also disclosed is a method for protecting against liquid leakage from a puncture wound in such a wall including: (a) preparing a generally elastomeric, pliable, layered coating mat of a self-puncture-healing, defined-liquid-reactive, anti-puncture-leakage material; (b) in relation to a selected container wall, selectively removing, by trimming, from the prepared mat one or more mat trims / tiles shaped for specific use on the outside surface of that wall; and (c) applying and surface-bonding the one or more trims / tiles to the outside surface of the selected wall.

Disclosed herein are non-dusting poly(phenylene ether) particles comprising 80 to 96 weight percent of poly(phenylene ether) particles having a mean particle size of 1 to 40 micrometers; and 4 to 20 weight percent of a liquid reactive diluent. Poly(alkenyl aromatic) resins, rubber-modified poly(alkenyl aromatic) resins, and hydrogenated, partially hydrogenated, and non-hydrogenated block copolymers of an alkenyl aromatic monomer and a conjugated diene are all excluded from the particles. The liquid reactive diluent is selected from a first polyol having at least two hydroxyl groups per molecule, a first epoxy resin, a first ethylenically unsaturated monomer, a polyether-modified polysiloxane, and combinations thereof. Also disclosed are compositions comprising the non-dusting poly(phenylene ether) particles and a thermoset composition, wherein the liquid reactive diluent is reactive with the components of the thermoset composition.

A technique for predicting fluid responsiveness in a critically ill patient comprises measuring physiological data of the patient, then generating an estimate of pulse pressure variability from a Fourier transform of the physiological waveform. Both invasive and non-invasive physiological data measurements may be used.

A fully automated ultrasound apparatus includes a sensor or probe which can be initially manually attached to a side of the neck of a patient, an ultrasound interface to control the sensor and periodically acquire raw ultrasound data, a signal and image processing system to autonomously convert the raw ultrasound data into a measurement that is useful to physicians, and a display to relay the current measurements and measurement history to provide data trends. The sensor can include one or more ultrasound transducers built into a housing. A disposable component can serve to secure the sensor to the neck of the patient and to provide a coupling medium between the sensor and the skin of the patient.

Anti-burst, anaconda-reaction liquid-container structure featuring both (I) a coating structure, per se, and (II), the overall organization of (A) a liquid container having a barrier wall with an outside surface, and, applied to the wall's outside surface, (B) coating structure possessing (1) a main body formed as a flexible expanse of anti-puncture-wound, self-sealing, high-elastomeric, material, and (2), embedded within, and distributed throughout, this expanse, (a) a population of distributed, container-contained liquid-reactive, liquid-imbiber elements, and (b) a web of restraining-fibre, expansion-following stretch-fabric

A method of manufacturing a composite insert includes forming a polymer mold from a polymer sheet which may have a glass transition temperature of 70 to 160° C., the polymer mold either includes a cavity or may form a cavity disposed between the polymer mold and the carrier. The method proceeds by depositing a liquid reactive composite insert composition, which may be a two-component composition including a first part comprised of an isocyanate-epoxy blend and a second part comprised of an alcohol-epoxy blend, into the cavity under low pressure conditions of 0-10 bar and low temperature conditions of 15-100° C. The composition is then allowed to become dimensionally stable either within the polymer mold or between the polymer mold and the carrier.

Methods for determining a cardiovascular parameter reflecting fluid or volume changes and for detecting arrhythmia are disclosed. These methods involve receiving a waveform dataset corresponding to an arterial blood pressure, pulseox, Doppler ultrasound or bioimpedance signal and analyzing the waveform to detect premature ventrical or atrial contractions. Premature ventrical or atrial contractions are detected, for example, by comparing parameters of individual cardiac cycles to the parameters of other or average cardiac cycles. If any premature ventrical or atrial contractions are present, they are removed from the waveform dataset. Once any the premature ventrical or atrial contractions are removed, a cardiovascular parameter reflecting fluid or volume changes using the modified waveform dataset is calculated. In the method for determining arrhythmia, if the number of premature ventrical or atrial contractions exceeds a predetermined arrhythmia threshold, a user such as a medical professional is notified.

A system (100) for assessing fluid responsiveness comprising: an infusion pump (24) in communication with at least one processor (32); and a plurality of physiological monitors (40, 42, 44, 46), It can be used to receive physiological signals from an associated patient. synchronizing physiological signals (48, 50) acquired from said associated patient (10) during a solution burst with a timing signal (54) of said infusion pump (24) administering said solution burst, according to One or more dynamic indicators and / or features (58) are calculated from the synchronized physiological signals (50) and based on the baseline physiological signals (48) collected from the associated patient (10) prior to administration of the solution burst to calculate one or more dynamic indicators and / or characteristics (50), based on the dynamic indicators and / or characteristics (58) from the synchronized physiological signal (50) and from the baseline physiological signal (48) The fluid responsiveness probability value (64) of said patient (10) is determined by the dynamic indication and / or characteristic (50) of said patient (10).

The invention provides a volume resuscitation triangle and resuscitation success rate prediction method and system thereof. The method comprises the following steps: obtaining lactic acid, central venous pressure and fluid responsiveness in real time according to a volume resuscitation triangle theory (proposed exclusively); predicting the resuscitation success rate according to a resuscitation success rate calculation formula; and performing result interpretation according to the predicted resuscitation success rate. According to the volume resuscitation triangle and the resuscitation success rate prediction method and system thereof provided by the invention, a set of optimization scheme which is considered according to the volume resuscitation triangle can be provided for different doctors during volume resuscitation, in order to reduce unnecessary errors.

A method for assessing volume responsiveness and medical equipment, the medical equipment comprising a respiratory assistance device (110) for providing breathing support to a patient, a first sensor (120) and a processor (140) for collecting physiological parameters of the patient , when volume responsiveness assessment is required, the processor controls the ventilation parameter to switch to the second ventilation parameter that can increase the variability of the patient’s intrathoracic pressure, and then at least uses the parameter variability measured under the second ventilation parameter that can reflect the patient’s heartbeat Assess the patient for fluid responsiveness. Because the second ventilation parameter can increase the variability of the patient's intrathoracic pressure, so that the variability of the parameters that can reflect the patient's heartbeat used to assess volume responsiveness increases, so it is possible to more accurately assess the patient's ability to respond to increased volume loading. No volume responsiveness.

A technique for predicting fluid responsiveness in a critically ill patient comprises measuring physiological data of the patient, then generating an estimate of pulse pressure variability from a Fourier transform of the physiological waveform. Both invasive and non-invasive physiological data measurements may be used.

In a method and breathing apparatus for prediction of fluid responsiveness of a subject connected to a breathing apparatus, at least one parameter is monitored that is indicative of a degree of carbon dioxide elimination of the subject, and a positive end expiratory pressure PEEP regulator of the breathing apparatus is operated to apply a PEEP maneuver in which a PEEP applied to the subject is changed from a first PEEP level to a second PEEP level. A processor predicts the fluid responsiveness of the subject based on a change in the monitored parameter, following the change in PEEP.

A method and apparatus is provided for determining a stroke volume (SV) of an individual, comprising the steps of: providing a first pulse contour stroke volume based on one or more characteristics ofa measured arterial blood pressure waveform or providing a conventionally derived pulse contour stroke volume, determining at least one perfusion parameter descriptive for the perfusion through the fat free mass and the adipose mass of a body of the individual, and / or determining at least one fluid responsiveness parameter function depending on a fluid responsiveness parameter descriptive for a heart-lung interaction of the individual, and adjusting the first pulse contour stroke volume or the conventionally derived pulse contour stroke volume based on at the least one of the perfusion parameter and / or the fluid responsiveness parameter function to provide a second pulse contour stroke volume.