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1 results about "Isopropylmalic acid" patented technology
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Isopropylmalic acid (isopropylmalate) is an intermediate in the biosynthesis of leucine, synthesized from oxoisovalerate by 2-isopropylmalate synthase and converted into isopropyl-3-oxosuccinate by 3-isopropylmalate dehydrogenase. Two isomers are important, the 2- and 3-isopropyl derivatives, and these are interconverted by isopropylmalate dehydratase.
Yeast platform
This disclosure relates to the field of bioengineered yeast strains as therapeutic platforms. In particular, to genetically modified strains of Saccharomyces bouloidii yeast containing modified 3-isopropylmalate dehydrogenase (Leu2) and nucleic acids encoding therapeutic proteins, as well as methods for treating or preventing diseases or conditions in subjects requiring such treatment.
Owner:FZATA INC