Effects of a physical memory fault are mitigated. In one example, to facilitate mitigation, memory is allocated to processing entities of a computing environment, such as applications, operating systems, or virtual machines, in a manner that minimizes impact to the computing environment in the event of a memory failure. Allocation includes using memory structure information, including, information regarding fault containment zones, to allocate memory to the processing entities. By allocating memory based on fault containment zones, a fault only affects a minimum number of processing entities.