The invention provides a bridge anti-collision system based on multiple protection devices. The bridge anti-collision system comprises a primary bridge body, fences, a secondary bridge body, bridge road-danger warning light devices, primary fixing plates, primary supporting rods, a wind indicator device, a secondary fixing plate, a secondary supporting rod, an inflatable air sac device, an adjustable maintaining plate device, an installing clamping plate device, a damping rebound pad device and an anti-collision rotating wheel device. According to the bridge anti-collision system based on the multiple protection devices, as a rubber wheel, a wheel shaft, a primary U-shaped protection frame and a secondary U-shaped protection frame are arranged, the protection effect can be achieved; meanwhile, when an automobile is crashed into a bridge, the automobile can be forced to be away from the bridge, and the once safety protection effect on the automobile and the bridge is achieved; as anti-playing clamping rings are arranged, it can be avoided that the rubber wheel is clamped, and the protection capacity is guaranteed; as a primary protection plate, buffer springs, a secondary protection plate and X-shaped frames are arranged, the multi-protection capacity can be improved, and the anti-collision effect of the bridge is guaranteed.