The invention discloses a signature method and device of an application program, equipment and a storage medium, the signature method of the application program comprises the following steps: receiving an application
certificate generation request of a development end, and when the application
certificate generation request carries a csr file, signing and issuing an application
certificate for the development end based on the csr file; the method comprises the following steps: acquiring application information of an application program to be signed, and signing and issuing a profi
authorization file by adopting a profi key pair and a profi signature certificate which are generated in advance based on the application information; and controlling the development end to sign the application
package data of the to-be-signed application program and the profi
authorization file based on the key pair stored in the development end and the application certificate. The application certificate and the profi
authorization file are automatically signed and issued for the application program according to the application certificate generation request sent by the development end, so that the development end can automatically perform
digital signature based on the application certificate and the profi authorization file, and the signature efficiency of the application program can be effectively improved.