The invention provides an organic electroluminescence device and a manufacturing method thereof. The organic electroluminescence device comprises a conductive anode substrate, a hole injection layer, a hole transmission layer, a light emitting layer, an electron transmission layer, an electron injection layer and a cathode which are stacked sequentially, wherein the hole injection layer is made of a mixture of rhenium oxide and zinc oxide, the hole injection layer further contains the binder polytetrafluoroethylene, the hole injection layer is of a nanometer netty structure, and the bore diameter of the nanometer netty structure is 100 nm - 150 nm. According to the organic electroluminescence device, the hole transmission layer is manufactured through mixture of rhenium oxide, azo substances, zinc oxide and polytetrafluoroethylene, the binder polytetrafluoroethylene enables the cohesiveness between the hole injection layer and adjacent layers to be improved, decomposition of the azo substances enables the nanometer netty structure of the hole injection layer to be formed, the hole transmission rate and the photoelectric conversion efficiency of the device can be improved, the manufacturing method is simple, and application prospects are good.