32 results about "Biopsy lesion" patented technology

The use of an iontophoresis electrode assembly for delivery of a drug formulation is described. The drug formulation includes an anaesthetic and a vasoconstrictor. It is administered to a patient prior to a procedure to produce clinically acceptable depth and duration of dermal anaesthesia at the portion of skin to subject to a painful procedure or to reduce or eliminate pain. The procedure is one selected from the group consisting of venipuncture, IV cannulation, needle aspirations, body piercings, blood donations, electrolysis, tattoo removal, tattoo application, injections, dermabrasion, skin peeling, high velocity particle ablation, pace maker implantation, pace maker replacement, epidural puncture, lumbar puncture, regional nerve blocks, skin harvesting, small skin incisions, skin biopsies, circumcisions or excisions. The iontophoresis electrode assembly may also be used to reduce or temporarily eliminate neuropathic pain.

Artificial dermis (1) obtained from plasma with platelets (2) and human fibroblasts. The plasma with platelets (2) is obtained from the fractionating of total blood (4) from the patient (8) by light centrifugation, and the human fibroblasts (3) from a skin biopsy (5). Clotting is obtained by adding calcium.This artificial dermis (1) provides for the rapid growth of the keratinocytes (6) seeded on its surface to build an artificial skin (7) which can easily be transplanted. Large areas of artificial dermis (1) are obtained from a small skin biopsy (5) and minimal quantities of plasma with platelets (2), which being enriched with cytokines and platelet growth factors, strengthens the proliferation of the cells seeded, both inside and on the surface.The artificial skin (7) obtained can be used to treat major burn treatments, chronic skin ulcers, etc., or be used, by employing genetically altered cells, as a vehicle for gene therapy.

The invention relates to an automatic device for performing skin biopsies, comprising a casing (2) housing a rod (3) on the distal end (3a) of which there is a circular blade (4), and means for causing simultaneous rotation and longitudinal advancement of the rod (3) from a first retracted position wherein the blade (4) of the rod (3) does not project via the distal end (2a) of the casing (2), to a second extended position wherein the blade (4) of the rod (3) projects via the distal end (2a) of the casing, followed by simultaneous rotation and longitudinal retraction of said rod (3) from said second extended position to said first retracted position.

Cells are generated from skin biopsies for use in cell implantation by identifying a source of skin cells that have a surface concentration of at least one cell selected from the group consisting of keritinocytes and / or melanocytes; taking a sample of tissue from the surface area; mechanically disaggregating the tissue samples; collecting the disaggregated cells; washing the disaggregated cells; filtering the washed disaggregated cells; providing a cell suspension with filtered and washed keritinocytes and / or melanocytes; and suspending the cell suspension in a medium. In greater particularity, the method may comprise a) identifying a source of skin cells that have a surface concentration of at least 400 cells per square millimeter of surface area of at least one cell selected from the group consisting of keritinocytes and / or melanocytes; b) taking a sample of those skin cells and culturing them to enrich for cells selected from the group consisting of keritinocytes and melanocytes to form cultured cells for transplantation purposes c) concentrating the cells selected from the group consisting of keritinocytes and / or melanocytes from the cultured mass of cells; and d) differentiating the concentrated cells selected from the group consisting of keritinocytes an / or melanocytes.

The invention discloses a device and method for segmenting cervical image lesion regions based on classification prior, wherein the device includes: an image acquisition device for collecting cervical images processed by 3%-5% acetic acid solution; a processor including cervical An image preprocessing module and a processing module, the processing module including a segmentation network model composed of a U-shaped network based on a residual connection, an image level classifier and a pixel level classifier, for outputting and predicting the position of the lesion area on the cervical image; The memory is used for storing the parameters of the segmentation network model in the processor; the display device is used for displaying the predicted lesion area output by the processor. The present invention can provide doctors with high-accuracy biopsy lesion position candidate regions, and improve the detection rate of biopsy positives.

Briefly stated, the present invention provides compositions and methods for treating or preventing joint injuries utilizing hair follicle derived Non-Bulbar Dermal Sheath (“NDBS”) cells. Within one aspect of the invention methods are provided for isolating NBDS cells, comprising the steps of: (a) preparing vital hair; (b) cleaving the hair prepared in step (a) to remove the hair follicle bulb; (c) isolating Non-Bulbar Dermal Sheath tissue; and (d) cultivating the isolated Non-Bulbar Dermal sheath tissue to produce NBDS cells. Within one embodiment of the invention the vital hair is obtained by full skin biopsy from the occipital scalp of a subject.

The present invention relates to a method for identifying pathological characteristics of skin biopsy images based on deep learning, which uses a multi-layer stacked autoencoder to re-express the features of the biopsy images, and uses a series of convolutional neural networks to convolve the image features layer by layer and sampling to obtain an abstract feature expression of the original skin biopsy image; the features obtained by the multi-layer stacked autoencoder and the convolutional neural network are spliced, and finally a multi-channel neural network is used to complete the identification of pathological characteristics. The present invention extracts abstract concept expressions through a deep learning model, and has strong adaptability to factors such as image color difference, illumination, magnification, thereby greatly improving the accuracy of computer recognition of pathological characteristics of skin biopsy images.

The invention discloses a skin biopsy trepan, belonging to a medical instrument. The skin biopsy trepan comprises a drill rod, a drill bit and a handle, wherein a piston and a push-pull rod are arranged in the drill rod; the handle is vertically arranged on one side of the upper end of the drill rod; a sliding pin is arranged in the handle and is provided with a wedged head for positioning the push-pull rod; the drill bit comprises a drill bit main body, a circular cutter and a slide bushing; the slide bushing is positioned outside the drill bit main body; a return spring is arranged below the slide bushing; the circular cutter is arranged outside the slide bushing; the lower end of the drill bit main body is provided with a perforated plate; and the lower end of the perforated plate is provided with a rubber pad. The skin biopsy trepan has the advantages of rational structure, convenience in operation and capabilities of greatly improving the sampling efficiency of pathological specimens and reliving the pain of a patient.