32 results about "Biopsy lesion" patented technology

An aqueous suspension of titanium dioxide, polymethylmethacrylate and Vitamin E oil is used to mark a location wherein a skin biopsy has been taken to enable subsequent identification of the biopsy location under ultraviolet light. The location is advantageously treated with Vitamin E oil on a daily basis subsequently extend the fluorescing life of the applied titanium dioxide.

Artificial dermis (1) obtained from plasma with platelets (2) and human fibroblasts. The plasma with platelets (2) is obtained from the fractionating of total blood (4) from the patient (8) by light centrifugation, and the human fibroblasts (3) from a skin biopsy (5). Clotting is obtained by adding calcium. This artificial dermis (1) provides for the rapid growth of the keratinocytes (6) seeded on its surface to build an artificial skin (7) which can easily be transplanted. Large areas of artificial dermis (1) are obtained from a small skin biopsy (5) and minimal quantities of plasma with platelets (2), which being enriched with cytokines and platelet growth factors, strengthens the proliferation of the cells seeded, both inside and on the surface. The artificial skin (7) obtained can be used to treat major burn treatments, chronic skin ulcers, etc., or be used, by employing genetically altered cells, as a vehicle for gene therapy.

An automated skin biopsy apparatus for taking a biopsy of a lesion on skin may include a suture applicator configured to controllably suture skin surrounding the lesion before the lesion is resected from the skin, a lesion resector configured to controllably resect the lesion from the skin, a user-operated control, and a controller. The controller may be configured, in response to actuation of the user-operated control by a user, to automatically cause the suture applicator to suture skin surrounding the lesion and the lesion resector to resect the lesion from the skin while the sutures from the suture applicator are in place. Related processes are disclosed.

Biosafety blade devices that aid in the manipulation and safety of either single-edged or double-edged razor blades are disclosed. The devices include finger guards that assist with holding and manipulating a razor blade. The device also includes various embodiments of blade guards that prevent accidental contact with the sharp edge of a razor blade, securely lock a blade preventing reuse, minimize recoil and flying projectiles, control the depth of a skin biopsy, reversibly fix blade curvature and allow for tissue to be measured and securely held to the blade or easily expelled into a specimen container. The components of the biosafety blade, i.e., the finger guards and blade guards, can be used separately or they can be combined to provide for maximum comfort, accuracy, versatility and safety.

The disclosure provides methods and compositions for the evaluation of neuropathic pain and neurotrophic or other activity of a drug or drug candidate. In the disclosed methods, expression of certain gene(s) in tissue extracts from skin biopsies serves as a proxy of a relevant endpoint.

An automated skin biopsy apparatus for taking a biopsy of a lesion on skin. The apparatus may include a lesion stabilizer configure to controllably stabilize the lesion while on the skin, a lesion resector configured to controllably resect the lesion from the skin, a user-operated control, and a controller. The controller may be configured to automatically cause, in response to actuation of the user-operated control by a user, the lesion stabilizer to stabilize the lesion while attached to the skin and the lesion resector to resect the lesion from the skin while the lesion is being stabilized by the lesion stabilizer. Related processes are also disclosed.

The invention discloses a skin biopsy trephine device which comprises a cylindrical trephine body with the two ends open. An annular cutter is arranged at the front end of the trephine body. A piston is arranged in the trephine body and connected with a push-pull rod. The free end of the push-pull rod extends out of a rear end opening of the trephine body and provided with a pushing handle. A cutting edge of the annular cutter is of a shuttle shape. Scale marks are arranged on the outer surface of the annular cutter in the length direction of the annular cutter. According to the skin biopsy trephine device, the cutting edge of the annular cutter is of the shuttle-shaped structure, compared with a circular cutting edge of an existing annular cutter, the shuttle-shaped cutting edge has the advantages that a wound surface is small, alignment suture is easy, healing is fast, and the phenomena of a dog ear and scars are not prone to generation; the scale marks are arranged on the outer surface of the annular cutter, the incision depth can be displayed and the material obtaining depth can be effectively controlled conveniently; in addition, the skin biopsy trephine device is made of metal except for the piston so that the device can be reused after being sterilized and disinfected and use cost can be reduced.

The invention provides a skin tissue pathological specimen collection tool, relates to a spring mode skin biopsy ring cutter, and belongs to the technical field of medical apparatus and instruments. The spring mode skin biopsy ring cutter comprises an outer sleeve, a middle sleeve, a depth regulating sleeve, a center slide bar, a reset cutting ferrule, a bayonet lock, a pressure spring, a reset spring, a ring cutter bit, an outer hoop, a release button and a depth dividing rule. The spring mode skin biopsy ring cutter is characterized in that the depth regulating sleeve is screwed onto the middle sleeve; the center slide bar penetrates into the middle sleeve; the reset cutting ferrule is glidingly arranged at the upper end of the center slide bar through the pressure spring and the reset spring; the outer sleeve is screwed onto the reset cutting ferrule; the ring cutter bit is screwed onto the lower end of the center slide bar; the outer hoop is fixedly arranged on the middle sleeve; the release button is arranged between the outer hoop and the middle sleeve. As a spring mode is adopted by the spring mode skin biopsy ring cutter, cutter feeding is finished instantly, and therefore, the operation time is greatly shortened, and the pain of a patient is reduced. The spring skin biopsy ring cutter is simple and convenient in operational process, and suitable for being clinically popularized and applied.

Skin-biopsy devices are provided that include a retractable coring assembly. Methods of acquiring a skin biopsy are provided that can include placing a lower portion of a skin-biopsy device proximate skin to be sampled, and extending at least a portion of a coring assembly from the device to acquire at least a portion of the skin to be sampled, and retracting the portion of the coring assembly to within the device, and discharging the portion of skin for analysis.

The invention provides a skin tissue pathological specimen collection tool, relates to a press-type skin biopsy ring cutter, and belongs to the technical field of medical apparatus and instruments. The press-type skin biopsy ring cutter comprises a press handle, a center slide bar, a reset spring, an outer sleeve, a middle sleeve, a cutter bit sheath and a ring cutter bit. The press-type skin biopsy ring cutter is characterized in that the outer sleeve and the cutter bit sheath are respectively screwed onto the middle sleeve; the press handle and the ring cutter head are respectively screwed onto the center slide bar; the center slide bar is arranged in the middle sleeve through the reset spring. According to the press-type skin biopsy ring cutter provided by the invention, the cylindrical stalloy ring cutter bit is adopted, and the outer wall of the middle sleeve is provided with a depth dividing rule, and thus, a sampled specimen has a regular edge, and is in the shape of a standard cylinder; moreover, depth is controllable, so that the sampling success rate is greatly improved. The press-type skin biopsy ring cutter provided by the invention is reasonable in structural design, capable of enhancing the operational stability, shortening the operation time, reducing the pain of patients, simple and convenient in operational process, and suitable for being clinically popularized and applied.

The invention provides a gathering tool of skin tissue pathological samples, in particular relates to a negative pressure skin biopsy trephine, and belongs to the technical field of medical instruments. The negative pressure skin biopsy trephine comprises a cylinder-shaped trephine body with two ends opened, and a ring-shaped ringing knife is arranged at the front end of the trephine body. The negative pressure skin biopsy trephine is characterized in that an annular rubber plug is arranged in the trephine body and is perpendicular to the inner wall of the trephine body; the front end of a metal pull rod is hinged with the rubber plug, and the rear end extends out of the rear end of the trephine body. The edges of the samples gathered by the ringing knife are tidy and are standard column-shaped, so that the phenomenon is avoided that since the samples are extruded by tweezers, the tissues are damaged, and the quality of samples is improved; the operation stability is increased due to a reasonable structural design; and meanwhile, the surgical time is shortened, the pain of a patient is reduced, and the operation process is simple, easy and convenient.

The subject of the present invention is to provide a detection method for latent viral infections by detecting a gene product related to latent infections without going through an invasive procedure involving pain and bleeding, caused by skin biopsy and blood collection. Further, the subject of the present invention is to provide a kit for examination using in the detection of latent viral infections described above. As crusts and scales in a lesion contain large amounts of virus-infected cells which are in a state of dry necrosis, the method collects crusts and/or scales for a test sample and detects a gene product related to latent infections which may be present in the test sample. The kit for examination comprises (1) antisense oligonucleotide for reverse transcription of a gene product related to latent viral infections, (2) a primer set for amplifying a gene product related to latent viral infections and (3) a primer set for amplifying a housekeeping gene.

Briefly stated, the present invention provides compositions and methods for treating or preventing joint injuries utilizing hair follicle derived Non-Bulbar Dermal Sheath (“NDBS”) cells. Within one aspect of the invention methods are provided for isolating NBDS cells, comprising the steps of: (a) preparing vital hair; (b) cleaving the hair prepared in step (a) to remove the hair follicle bulb; (c) isolating Non-Bulbar Dermal Sheath tissue; and (d) cultivating the isolated Non-Bulbar Dermal sheath tissue to produce NBDS cells. Within one embodiment of the invention the vital hair is obtained by full skin biopsy from the occipital scalp of a subject.

The invention discloses a skin cancer classification method based on the optical intensity and gradient of an OCT imaging image, and the method comprises the steps: (1) collecting a skin cancer imagethrough an OCT device, and normalizing the intensity in the OCT image into [0, 1]; (2) performing noise reduction on the OCT image through noise reduction processing; (3) extracting optical intensitycharacteristic parameters; (4) calculating to obtain the discrete value of each parameter of the marked sample, and then obtaining the difference and ROC analysis of each characteristic parameter in the marked control group through a mathematical statistics method to obtain a boundary value; and (5) calculating to obtain the discrete value of each parameter of the unknown sample, comparing the discrete value with the boundary value in the step (4), and classifying the unknown sample according to the comparison result. According to the invention, normal skin tissues, melanoma and melanin nevuscan be quickly and accurately judged; discomfort and trauma brought to a patient by an invasive method of skin biopsy are avoided.

A skin biopsy device and a method of operating a skin biopsy device are disclosed. The skin biopsy device comprises a base member configured to be placed onto a skin surface; an cutting member configured to be received by the base member and to be movable relative to the base member in a direction substantially orthogonal to the skin surface; and an actuation member configured to drive the cutting member to travel a predetermined distance at a predetermined velocity in said direction.

The invention discloses a skin tissue drilling device. The skin tissue drilling device comprises a handle and an annular drill bit which are connected with each other, and an observation hole is formed in the side wall of the annular drill bit, and formed in the axial direction of the annular drill bit; the observation hole is a kidney-shaped hole; a set of concave openings are formed in a blade of the annular drill bit along the circumference; the blade of the annular drill bit is in a circular truncated cone shape. When skin biopsy is conducted, through the observation hole, the biopsy depthcan be directly observed, and thus the sampling accuracy and reliability are improved; the annular drill bit is provided with the concave openings, so that the concave openings are in a sawtooth shape, the blade is in the circular truncated cone shape, and rotary drilling during skin biopsy is facilitated.

The invention provides an oral cavity diseased tissue observation instrument, and relates to the field of medical tools. The oral cavity diseased tissue observation instrument comprises a device body, a skin biopsy device is arranged in the right end of the device body, and the left end of the skin biopsy device is clamped in the right end of a connecting sleeve. The electric motor drives the threaded column to rotate, so that the threaded plate can be driven to move along the threaded column, the skin biopsy device can stretch out and draw back in the probe under the driving of the connecting plate and the connecting sleeve, the sleeve is fixed to the left end of the connecting plate, the sleeve can stretch out and draw back and has a stretching range, and the threaded plate can be limited through the sleeve; the skin biopsy device can be driven to swing through the sleeve and the connecting block by rotating the pulley, so that the angle of the skin biopsy device can be adjusted, pathological tissues can be sampled through the skin biopsy device, and meanwhile, absorbent cotton can be arranged at a port of the skin biopsy device, so that the pathological parts can be accurately applied with medicine and stopped bleeding through the skin biopsy device.

The present invention relates to a minimally invasive skin biopsy method. The minimally invasive skin biopsy method according to the present invention comprises the steps of: preparing a microneedle patch; attaching the microneedle patch to the skin of a patient; keeping the microneedle patch attached to the skin of the patient for a predetermined time; and after the predetermined time has elapsed, detaching the microneedle patch from the skin of the patient to analyze protein components of the patient's skin, with which the microneedle is stained. The microneedle is made of a biocompatible polymer material.

In order to solve deficiencies of the existing skin sampling methods, the present invention aims to provide a skin sampler with a simple structure and convenient operation. The sampler comprises 1, astainless steel sampling tube, 2, a non-slip printed handle, 3, a movable plunger, and 4, a compression spring. The sampler is simple in structure, can also liable to take tissues or conduct punching,and reduces work difficulty of medical staff.