The invention discloses a tooth belt double-shaft guide rod groove cam combination space mechanism for a sliding-plug door, relates to a sliding and plug, sealing, opening and closing mechanism for the sliding-plug door for a vehicle, in particular to the tooth belt double-shaft guide rod groove cam combination space mechanism for high-speed rail or other railway vehicles. The mechanism comprises a door frame, a motor, a driving wheel, a tooth belt, an auxiliary bearing shaft, a belt clamp, a tension device, a bearing pedestal, a driven wheel, an auxiliary shaft sleeve, a coupling rod A, a main shaft sleeve, a main bearing shaft, a coupling shaft B, a coupling shaft C, a guide rod sleeve, a roller, a roller shaft, a door carrying guide rod, a groove cam and a door leaf; a tooth belt transmission mechanism consists of the driving wheel, the tooth belt, a lower belt clamp, the tension device, the bearing pedestal, and the driven wheel; a double-shaft guide rod mechanism consists of the coupling rod A, the main shaft sleeve, the coupling rod B, the coupling rod C and the guide rod sleeve which are connected fixedly and integrally, the main bearing shaft, the auxiliary shaft, and the door frame; and a groove cam mechanism consists of the main shaft sleeve, the main shaft, the coupling rod C, the roller, the roller shaft, the door carrying guide rod, the groove cam, the door leaf, the main shaft sleeve and the door frame.