The invention relates to a tooth strap, single shaft and guide rod, and groove-shaped cam combined spatial mechanism of a sliding plug door, which relates to an open and close mechanism of sliding plug hermetization of the sliding plug door of a vehicle, in particular to the tooth strap, single shaft and guide rod, and groove-shaped cam combined spatial mechanism of the sliding plug door of a high-speed railway vehicle and other railway vehicles. The tooth strap, single shaft and guide rod, and groove-shaped cam combined spatial mechanism comprises a door frame, a motor, a driving tooth gear, a tooth strap, a load-bearing shaft, a strap clamp, a tensioning device, a bearing seat, a driven tooth gear, a load-bearing shaft sleeve, a connecting rod, a guide rod sleeve, a door carrying guide rod, a roller, a roller shaft, a groove-shaped cam and a door leaf; a tooth strap mechanism comprises the driving tooth gear, the tooth strap, the strap clamp, the tensioning device, the bearing seat and the driven tooth gear, and the strap clamp is fixedly connected with the load-bearing shaft sleeve, the connecting rod and the guide rod sleeve into a whole so as to form a single shaft and guide rod mechanism with the load-bearing shaft, the door carrying guide rod, the door frame and the like; and a groove-shaped cam mechanism comprises the load-bearing shaft, the load-bearing shaft sleeve, the guide rod sleeve, the roller, the roller shaft, the door carrying guide rod, the groove-shaped cam and the door leaf, and the three mechanisms are connected with one another to form the tooth strap, single shaft and guide rod, and groove-shaped cam combined spatial mechanism.