13 results about "Gastro enteritis" patented technology

The invention discloses a composition for treating insomnia. Comprising probiotic compounds: lactobacillus plantarum, bifidobacterium lactis, lactobacillus crispatus, lactobacillus acidophilus, lactobacillus rhamnosus, bifidobacterium bifidum, lactobacillus reuteri, lactobacillus casei, lactobacillus bulgaricus, lactobacillus fermentum, lactobacillus gasseri, lactococcus lactis, bifidobacterium longum, lactobacillus salivarius, bifidobacterium breve, streptococcus thermophilus and lactobacillus paracasei; lactobacillus helveticus; and traditional Chinese medicine components and prebiotics. Probiotics are matched with traditional Chinese medicines with homology of medicine and food, and corresponding prebiotics are supplemented, so that the balance of intestinal flora can be adjusted and information transmission between intestines and cranial nerves can be promoted through the synergistic effect of the probiotics and the corresponding prebiotics, and then gastrointestinal inflammation, ulcer, helicobacter pylori infection, constipation and insomnia are treated or improved; and treating or improving spleen and stomach disharmony, liver qi stagnation, excessive heart fire, fire excess from yin deficiency, heart-kidney disharmony caused by emotion, pressure, diseases and the like, and insomnia caused by the symptoms.

The invention provides a traditional Chinese medicine composition for maintaining and conditioning intestines and stomach. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 4-8 parts of a traditional Chinese medicine extract A, 2-8 parts of a traditional Chinese medicine extract B, 4-6 parts of a traditional Chinese medicine extract C and 6-12 parts of a traditional Chinese medicine extract D. According to the traditional Chinese medicine composition, coix seeds, almonds, Chinese yams, lotus seeds, gordon euryale seeds and hericium erinaceus are used as a formula, the components are extracted, separated, enriched and purified through different methods to obtain extracts of different components, the extracts are reasonably proportioned, and the prepared traditional Chinese medicine composition can obviously relieve hyperacidity and abnormal intestinal peristalsis (too fast or too slow), and has the effects of improving the immunity and improving the immunity. Therefore, acute and chronic gastroenteritis reactions such as abdominal distension, diarrhea and constipation are caused, and the effects of maintaining and conditioning the stomach and the intestine are achieved.

Every year, approximately 94 million cases of Salmonella gastroenteritis, with 155000 deaths, are reported each year and 85% of them reported to be food-borne. Investigation of the foods whether they are clean for Salmonella and sensitivity, easy applicability, absence of false positivity and negativity and the speed are the features sought in the analysis method for this investigation. It is not desirable for analysis to detect the presence of dead bacteria in food. Although the final product does not contain microbiologically harmful live bacteria during the food process, the detection of dead bacteria transmitted before the process causes the food product to be unfairly diagnosed as harmful. To prevent this situation, the analysis kits depending on molecular methods, increase their microorganism detection levels up to to 104 while reducing their sensitivity. Since the molecular methods cannot discriminate dead and live organisms, a confirmation test is required to prove that the positive result of the analysis belongs to the live bacteria in the food, which results in additional cost and time loss. In the same way, it is necessary to verify whether the colonies that grow in the gold standard culture method, belong to Salmonella bacteria. In the developed system; 105 dead bacterial DNA is eliminated in the food to prevent false positive results and the minimum detection limit is 10 bacteria. Also, in developed system, 4 primers specific to 6 regions of DNA are used. Therefore, the specificity of the method is very high (99.9%) and no verification test is needed. Since PCR systems require a device with complex temperature control units, they can make analysis in a laboratory-dependent manner. In the proposed system, DNA is amplified at constant temperature; no temperature cycle is required, therefore no complex instrument and laboratory infrastructure are required. All the procedures can be easily performed outside the laboratory on a portable mini-heater where pre-enrichment, DNA isolation from the sample and PCR steps are performed. For molecular analyses, the device is required to display the result of imaging or analysis. In the developed method, DNAs amplified by the loop-mediated isothermal DNA amplification method, are hybridized and combined with the labeled probe and then can be read by lateral flow method with the naked eye. As the results are visible by eye, no additional device is required. The classical culture method is accepted as the gold standard, but the duration of analysis is 7 days for positive samples, 3 days with verification test, for the molecular methods, and 5.5 hours including pre-enrichment time in the developed system.

Provided herein is a bulk composition comprising the trihydrate form of (3S, 4R, 3′R)-6-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-azabicyclo[2.2.2]oct-3′-yl ester di-hydrochloride salt. Provided are also pharmaceutical compositions and dosage forms comprising the trihydrate form, and methods and uses for treating a gastrointestinal disorder in a subject with the trihydrate form. In some embodiments, the gastrointestinal disorder is gastroesophageal reflux disease (GERD), dyspepsia (such as functional dyspepsia or functional motility disorder), gastroparesis, paralytic ileus, post-operative ileus, emesis, nausea, heartburn, intestinal pseudo-obstruction, irritable bowel syndrome (IBS), constipation, enteral feeding intolerance (EFI), or esophagitis. In some embodiments, the gastrointestinal disorder is post-operative ileus, chronic grass sickness, constipation, megacolon, gastritis, gastrointestinal stasis, or abomasal emptying defect.

Provided herein is a bulk composition comprising the trihydrate form of (3S, 4R, 3′R)-6-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-azabicyclo[2.2.2]oct-3′-yl ester di-hydrochloride salt. Provided are also pharmaceutical compositions and dosage forms comprising the trihydrate form, and methods and uses for treating a gastrointestinal disorder in a subject with the trihydrate form. In some embodiments, the gastrointestinal disorder is gastroesophageal reflux disease (GERD), dyspepsia (such as functional dyspepsia or functional motility disorder), gastroparesis, paralytic ileus, post-operative ileus, emesis, nausea, heartburn, intestinal pseudo-obstruction, irritable bowel syndrome (IBS), constipation, enteral feeding intolerance (EFI), or esophagitis. In some embodiments, the gastrointestinal disorder is post-operative ileus, chronic grass sickness, constipation, megacolon, gastritis, gastrointestinal stasis, or abomasal emptying defect.

The present invention discloses a novel chalcone compound, a preparation method, a pharmaceutical composition, and applications thereof, belonging to the field of pharmaceutical technology. The chalcone compound (±)-Lupulusone A provided by the present invention has not been reported to date. Experimental results show that the chalcone compound provided by the present invention has significant anti-inflammatory activity against lipopolysaccharide-induced RAW 264.7 cells, significantly superior to the positive drug dexamethasone. It can be used to develop drugs for treating various inflammatory-related diseases, including but not limited to pneumonia, hepatitis, nephritis, arthritis, conjunctivitis, gastroenteritis, metabolic syndrome, diabetes, cancer, etc.

The invention relates to the technical field of gastrointestinal disease treatment, and discloses a traditional Chinese medicine composition for treating gastrointestinal diseases and a preparation method thereof, and the traditional Chinese medicine composition is prepared from the following materials: angelica sinensis, radix paeoniae alba, ligusticum wallichii, ginseng, bighead atractylodes rhizome, poria cocos, cassia twig, rhizoma bletillae and deionized water. According to the traditional Chinese medicine composition for treating gastrointestinal diseases and the preparation method of the traditional Chinese medicine composition, traditional Chinese medicine capsules prepared by the invention have the effects of relieving pain and stopping dysentery, have an excellent effect on patients accompanied by angina pectoris and bloody stool, have the effects of nourishing blood and regulating menstruation, astringing yin and stopping sweating, nourishing liver and relieving pain, and stabilizing liver yang by adding radix paeoniae alba, and can be used for treating gastrointestinal diseases. The traditional Chinese medicine composition can also be used for treating headache, dizziness and hypochondriac pain caused by deficiency of liver yin, uncomfortable liver qi and hyperactivity of liver yang, and has the effects of dispersing depression, removing stasis and strengthening the five internal organs, the added ligusticum wallichii has the effects of activating blood, promoting qi circulation, dispelling wind and relieving pain, development of gastrointestinal diseases such as acute gastroenteritis is effectively restrained through matching of the ligusticum wallichii and the traditional Chinese medicine composition, and the illness state is rapidly controlled.

Provided herein is a bulk composition comprising the trihydrate form of (3S, 4R, 3′R)-6-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-azabicyclo[2.2.2]oct-3′-yl ester di-hydrochloride salt. Provided are also pharmaceutical compositions and dosage forms comprising the trihydrate form, and methods and uses for treating a gastrointestinal disorder in a subject with the trihydrate form. In some embodiments, the gastrointestinal disorder is gastroesophageal reflux disease (GERD), dyspepsia (such as functional dyspepsia or functional motility disorder), gastroparesis, paralytic ileus, post-operative ileus, emesis, nausea, heartburn, intestinal pseudo-obstruction, irritable bowel syndrome (IBS), constipation, enteral feeding intolerance (EFI), or esophagitis. In some embodiments, the gastrointestinal disorder is post-operative ileus, chronic grass sickness, constipation, megacolon, gastritis, gastrointestinal stasis, or abomasal emptying defect.

The invention discloses a preparation method of a coix seed and tartary buckwheat tea bag. The tea bag comprises the following components in parts by weight: 4-6 parts of coix seeds, 4-6 parts of tartary buckwheat, 0.5-0.75 part of stevia rebaudiana, 0.8-1.2 parts of Chinese wolfberry fruits, 1-1.5 parts of cape jasmine fruits and 1-1.5 parts of honeysuckle flowers. Certain auxiliary effects are achieved on hyperlipidemia, enterogastritis, gastrointestinal indigestion and diabetes mellitus; various active substances are contained, so that liver detoxification can be promoted, and liver health can be protected; therefore, the tea is suitable for most people to drink.

The invention discloses a preparation method and application of a probiotic-drug oral co-delivery system, a method of coating probiotics with phospholipid and coating indissolvable drugs with cyclodextrin is adopted, so that the stability and activity of the probiotics in an acid environment of gastric acid are ensured, the damage of gastric juice to the probiotics is effectively reduced, and the bioavailability of the oral co-delivery system is improved. Enough viable bacteria quantity and vigor reach the intestinal tract are ensured, the stability of the treatment effect is ensured, the problem that the expected effect cannot be exerted due to insufficient viable bacteria quantity is avoided, and the infection risks such as acute gastroenteritis and urethritis possibly caused by excessive viable bacteria quantity are prevented; the traditional Chinese medicine composition has good adaptability, can immediately exert a treatment effect without dormancy adjustment, can rapidly and effectively supplement probiotics, is safe and harmless to human bodies, does not generate toxic or side effects after being taken, is simple and convenient in preparation method, is easy to operate, is suitable for industrial large-scale production, and has a wide application prospect. An efficient and safe new scheme is provided for treating intestinal inflammation through co-delivery of probiotics and chemical drugs.

The invention discloses a medicine capable of treating diseases and resisting aging and a preparation method thereof. The medicine comprises the following components in parts by mass: 9 parts of American ginseng, 9 parts of saffron crocus, 9 parts of antelope horn, 9 parts of cornu cervi pantotrichum, 15 parts of radix rehmanniae, 15 parts of radix rehmanniae preparata, 15 parts of Chinese yam, 15 parts of semen cuscutae, 15 parts of mantis egg-case, 15 parts of pulp of dogwood fruit, 15 parts of rhizoma anemarrhenae, 15 parts of cortex lycii radicis, 16 parts of rhizoma alismatis, 12 parts of gastrodia elata, 12 parts of cistanche, 20 parts of astragalus membranaceus, 20 parts of mulberry, 20 parts of eclipta, 20 parts of rheum officinale, 20 parts of tendril-leaved fritillary bulb, 50 parts of caulis spatholobi, 16 parts of semen allii tuberosi, 30 parts of fructus lycii and 16 parts of glossy privet fruit. The preparation method comprises the following steps: soaking in yellow rice wine, decocting to obtain liquid medicine, and concentrating to prepare the soft capsule. The preparation method comprises the following steps of: adding a mixture of 9 parts of deer-horn glue, 9 parts of tortoise-plastron glue and 0.3 part of musk into the lixivium of 16 parts of cherokee rose fruit. The medicine disclosed by the invention can be used for treating diseases such as three highs, heart diseases, chronic gastroenteritis, senile osteoarthritis and the like, and has an effect of prolonging the life of a human body.

The invention relates to the technical field of pet food preparation, in particular to a basic ration additive for relieving gastroenteritis and a preparation method and application thereof. The catalyst comprises the following substances in parts by weight: 80-85 parts of a carrier; 5-10 parts of a yeast cell wall extract; 1-3 parts of enzymolysis oat fiber; 0.5 to 1 part of apple fiber; 0.1 to 0.3 part of ascorbic acid; 0.5 to 1 part of a prebiotic oligosaccharide compound; and 0.5-1 part of an antioxidant. Enzymatic oat fibers, apple fibers, ascorbic acid and prebiotic oligosaccharide compounds for improving intestinal tracts are added into the basic ration for cats to achieve a synergistic effect, so that diarrhea and intestinal inflammation symptoms of the cats during enterogastritis can be relieved.

Nutraceutical compositions and methods of their use in treating Caliciviridae family viruses are provided. The viruses can be norovirus or sapovirus. An exemplary nutraceutical composition includes Fagopyrum dibotrys extract. Another nutraceutical composition for treating viral gastroenteritis includes 5, 7, 3′, 4′-tetrahydroxyflavan-3-ol C4-C8 dimers, quercetin, rutin, or a combination thereof. The nutraceutical compositions inhibit or reduce entry of Caliciviridae family viruses into intestinal epithelial cells of the subject.