50 results about "Glycogen phosphorylase" patented technology

A compound of formula I wherein W is a bicyclic hetroaryl of the structure X is —O—, —S—, —SO2—, —CHR5—, —CHR5O—, —CHR5S—, —CHR5SO2—, —CHR5CO— or —CH2CHR5—; Y is a bond or —CHR6—; Z is an aryl or heteroaryl group of the following structure: A is —CH— or —N—; B is —O— or —S—; and R1, R2, R3, R4, R5, R6, R7 and R8 are as described herein. Further provided is a method for treating diabetes and related diseases employing a glycogen phosphorylase inhibiting amount of the above compound, either alone or in combination with another therapeutic agent.

The invention relates to an azo bond contained glycogen phosphorylase inhibitor cholic acid derivative, a preparation method thereof and a pharmaceutical composition containing the same. The azo bond contained glycogen phosphorylase inhibitor cholic acid derivative is a liver-targeted pro-drug for glycogen phosphorylase; compared with a glycogen phosphorylase inhibitor, the concentration of the glycogen phosphorylase inhibitor in a liver can be increased after the glycogen phosphorylase inhibitor cholic acid derivative is taken orally, so that the glycogen phosphorylase inhibitor cholic acid derivative can serve as a preferred drug for lowering blood sugar, particularly for treating impaired fasting glucose. The compound can be used for preventing and treating diabetes and complications thereof, hyperlipidemia, obesity, high-glucagon disease, insulin resistance, impaired fasting glucose, hypertension and complications thereof, atherosclerosis, metabolic syndrome or tumor.

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

The invention features pharmaceutically active quinoxalinones of formula (1), compositions containing them, and methods of making and using theme: Formula (I) wherein R<1> is H, C 1-6 alkyl, or halo; R<2> is H or halo; R<3> is H, C 1-6 alkyl, X is N or CH; Y is a covalent bond, -NHCO- or -CONH-; Z is phenyl or a 5 or 6-membered heterocyclyl with between l and 2 heteroatoms independently selected from N, O, and S; and n is 0, 1 or 2; or a pharmaceutically acceptable salt, ester, amide, hydrate, or solvate thereof; as well as their use as glycogen phosphorylase inhibitors for the treatment of i diabetes and obesity.

The invention discloses a wolfberry seed wall-breaking pretreatment agent, the components of which are, in parts by weight, 100 parts of ethanol, 35-40 parts of Andrographis paniculata extract, 20-23 parts of glycogen phosphorylase, and hydroxyethylidene diphosphonic acid 18-22 parts, 2-5 parts of cellulase, 0.1-1 part of triethylamine. The wolfberry seed wall-breaking treatment solution provided by the present invention can modify the cell wall of wolfberry seeds, and then perform mechanical wall breaking after becoming soft. Not only the wall breaking rate is high, but also the wall breaking can be completed quickly in a short time, effectively Avoid the invasion of bacteria.

The invention relates to a kind of glycogen phosphorylase inhibitor cholic acid derivatives containing biocleavable dipeptides, their preparation method and their drug combination. The derivatives are liver-targeting prodrugs of glycogen phosphorylase, and the biocleavable dipeptide can be cleaved by enzymes in vivo to release glycogen phosphorylase inhibitors. Such compounds can be used to prevent and treat diabetes and its complications, hyperlipidemia, obesity, hyperglucagonism, insulin resistance, fasting hyperglycemia, hypertension and its complications, atherosclerosis, metabolic Syndrome or tumor.

The invention discloses a near infrared fluorescence detection kit for glycogen phosphorylase isoenzyme BB and application of the near infrared fluorescence detection kit. The near infrared fluorescence detection kit comprises a reagent strip on a backboard, wherein the reagent strip comprises a sample pad, a glass fiber film marked by an immunofluorescence probe, a nitrocellulose membrane coated by the anti-glycogen phosphorylase isoenzyme BB antibody, and absorbent paper. According to the invention, by combining with the near infrared fluorescence detection technology, the detection kit can rapidly and accurately detect the glycogen phosphorylase isoenzyme BB in human whole blood, serum and plasma.

The present invention relates to the compound of heterozolotriazole ring and indole carboxylic acid represented by formula (I) having glycogen phosphorylase inhibitory activity and its salt, its preparation method and its preparation for treatment and / or prevention and treatment. Use in medicine for diseases related to abnormal glycogen metabolism.