78 results about "LBP - low back pain" patented technology

A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

The disclosure relates to compounds of formula I, wherein X, and R1-R4, n, and m have the meaning given in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I exhibit GPR 183 antagonistic activity and are thus useful in the treatment or prevention of disorder, condition, or disease where GRP183 antagonist is indicated to be useful, such as e.g. chronic pain e.g osteoarthritis, chronic low back pain, neuropathic pain and immune system diseases e.g inflammatory bowel diseases e.g. Colitis and Chron's diseases, multiple sclerosis, rheumatoid arthritis, inflammatory pulmonary diseases e.g. asthma and psoriasis.

The invention provides a muscle fatigue detection method and device based on a multi-modal physiological information graph, electronic equipment and a storage medium, and relates to the field of biological information. The method comprises the steps that space-time synchronization signals of a target muscle group are acquired, and the space-time synchronization signals comprise electromyographic signals and muscle oxygen signals; performing data preprocessing on the space-time synchronization signal to extract a target characteristic parameter reflecting a muscle fatigue state; performing visualization processing based on the target characteristic parameters to obtain a multi-modal physiological information graph; and inputting the multi-modal physiological information graph as input data into a target detection model to obtain a muscle fatigue classification result. Therefore, the fusion of the multi-modal physiological information graph is realized based on the acquired space-time synchronization signal and the target detection model, then the identification of muscle fatigue is completed, the objectivity and accuracy of waist and back muscle fatigue detection and classification are finally improved, and an objective and effective prevention means is provided for preventing chronic lumbago and acute muscle injury.

Described herein are various implementations of systems and methods for controllably accessing and modulating tissue (for example, systems and methods for accessing and ablating nerves or other tissue within or surrounding a vertebral body to treat chronic low back pain).

The present application proposes a medicine for treating lumbago and a preparation method thereof, and relates to the technical field of traditional Chinese medicine. A medicine for treating lumbago, comprising the following raw materials in weight: 40-60 parts of costusroot, 0.1-0.5 parts of musk, 1-5 parts of green peel, 5-10 parts of cyperus, 5-10 parts of agarwood, 5-10 parts of bupleurum, 1-5 parts of clematis and 5-15 parts of chuanxiong. The inventor of the present application uses costusroot as the main medicine, first relieving symptoms, dredging meridians, promoting qi and removing stagnation, and unblocking meridians; assisted by musk to promote blood circulation and reduce swelling, green peel and cyperus to soothe the liver and produce blood, agarwood to relieve pain and promote qi, bupleurum to warm the kidney yang and nourish the liver and blood, clematis to dredge the meridians and relieve pain, chuanxiong to remove blood stasis, multiple drugs synergistically act, comprehensively play the effects of strengthening the liver and kidney, unblocking the meridians and removing blood stasis, treating both the symptoms and the root causes of lumbago, fundamentally curing lumbago, so that lumbago no longer recurs.

The present invention relates to a system and method configured for analysing acoustic parameters of speech to detect, diagnose, predict and / or monitor progression of a condition, disorder, or disease, and more particularly, any of paediatric and adult neurological and central nervous system conditions including but not limited to low back pain, multiple sclerosis, stroke, seizures, Alzheimer's disease, Parkinson's disease, dementia, motor neuron disease, muscular atrophy, acquired brain injury, cancers involving neurological deficits, paediatric developmental conditions and rare genetic disorders such as spinal muscular atrophy. The system and method extracts a first formant data set from words spoken by an individual and uses these to classify the vowels in the words on a first computing device, such as a mobile smart phone equipped with a microphone into which an individual speaks. The system stores at least some of these frequencies for the vowel formants in a second formant data set as a recorded file and provides the second formant data set as input to acoustic metrics to generate score data from which an assessment is made to determine the articulation level of the vowels in the words spoken by the individual, allowing allow for detection, diagnosis, prediction and / or monitoring progression of the condition, disorder, or disease.

Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region from an epidural, cervical location to address at least one of high back pain, mid-back pain, low back pain, and leg pain without creating paresthesia in the patient.

The present disclosure relates to compounds of Formula I and pharmaceutically acceptable salts thereof, wherein X, R1-R4, n and m have the meanings given in the specification. The compounds of formula I exhibit GPR183 antagonistic activity and are therefore useful in the treatment or prevention of disorders, conditions or diseases to which GRP183 antagonists are applicable, such as chronic pain, such as osteoarthritis, chronic lumbago, neuropathic pain, and immune system diseases, such as inflammatory bowel diseases, such as colitis and Crohn's disease, multiple sclerosis, rheumatoid arthritis, inflammatory lung diseases, and the like. , such as asthma and psoriasis.

The invention relates to gastrodia elata dizziness-relieving granules and a preparation method thereof. Gastrodia elata, rhizoma pinellinae praeparata, uncaria rhynchophylla, concha haliotidis, rhizoma atractylodis macrocephalae, lumbricus, radix curcumae, rhizoma acori graminei, poria cocos, pericarpium citri reticulatae, herba siegesbeckiae, rhizoma alismatis and liquorice are selected as raw materials, the raw materials are decocted, filtered, concentrated and granulated, the obtained gastrodia elata dizziness-relieving granules are fragrant in smell and slightly bitter and astringent in taste, all the materials are selected from natural traditional Chinese medicine components, and the gastrodia elata dizziness-relieving granules have the effects of relieving spasm by wind, tonifying spleen, reducing phlegm and promoting blood circulation to remove meridian obstruction; the traditional Chinese medicine composition has certain curative effects on symptoms such as dizziness, dizziness, head pain, chest rib stuffiness and pain, vexation, irritability, excessive phlegm, tinnitus and waist soreness and weakness caused by phlegm-dampness accumulation, upward disturbance of liver wind and meridian stasis, has no side effect on the body and is beneficial to health; the preparation method is simple, low in production cost and beneficial to popularization and application.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a ginseng and licorice root formula for treating renal hematuria, its preparation method, and its application. The ginseng and licorice root formula for treating renal hematuria of this invention comprises the following raw materials in parts by weight: 5-15 parts of Codonopsis pilosula, 15-30 parts of Rehmannia glutinosa, 5-15 parts of Ligustrum lucidum, 5-15 parts of Eclipta prostrata, 5-15 parts of Imperata cylindrica, 5-15 parts of Rubia cordifolia, 5-15 parts of Cirsium japonicum, 5-15 parts of Taraxacum mongolicum, 5-8 parts of Prunus persica, and 3-5 parts of Glycyrrhiza uralensis. Clinical trials have shown that the ginseng and licorice root formula for treating renal hematuria of this invention not only reduces urinary red blood cells but also improves traditional Chinese medicine clinical symptoms such as lower back and knee weakness, fixed or stabbing lower back pain, pale complexion, fatigue, dry mouth, bitter taste, sore throat, rough skin, and poor appetite. It has good therapeutic effects, reliable safety, and can significantly improve the treatment efficacy of chronic nephritis syndrome.

The invention provides a chronic lumbago surface electromyogram discrimination method and system based on a Fourier analysis neural network and a storage medium, and the method comprises the steps: firstly obtaining a data set which comprises a plurality of surface electromyogram signals and corresponding real labels; preprocessing the surface electromyogram signal to obtain a preprocessed surface electromyogram signal; inputting the preprocessed surface electromyogram signals into a constructed neural network based on Fourier analysis to obtain a prediction label of each surface electromyogram signal; constructing a loss function according to the real label and the predicted label, and training the neural network based on Fourier analysis to obtain a trained neural network based on Fourier analysis; and inputting a surface electromyogram signal to be detected into the trained neural network based on Fourier analysis to obtain a corresponding prediction label. According to the method, the neural network based on Fourier analysis is constructed and trained, the potential periodic features with discrimination are extracted, automatic discrimination of the abnormal modes in the chronic lumbago surface electromyogram signals is achieved, and therefore discrimination with higher robustness, higher generalization and higher efficiency is achieved.

The invention discloses a traditional Chinese medicine composition for treating lumbago and application of the traditional Chinese medicine composition. Rehmannia glutinosa, astragalus membranaceus and radix puerariae are used as monarch drugs; black prepared common monkshood daughter root, dried ginger, cassia twig, asarum, pseudo-ginseng, safflower and the like are used as ministerial drugs; gleditsia sinensis lam, semen brassicae, radix scutellariae, fructus arctii, radix paeoniae alba, fructus lycii, rhizoma atractylodis macrocephalae and the like are used as adjuvant drugs, radix bupleuri, cudrania cochinchinensis, radix dipsaci, eucommia ulmoides, herba epimedii and cynomorium songaricum are used as adjuvant drugs, radix bupleuri is used for soothing liver and regulating qi, and lifting qi to strengthen yang and warm qi, cudrania cochinchinensis is used for promoting blood circulation to remove meridian obstruction, and radix puerariae is used for relieving muscles and relaxing tendons and removing stasis and removing food retention. The traditional Chinese medicine can effectively treat kidney-yang deficiency type and complex lumbago (such as lumbar muscle degeneration, lumbar disc herniation and osteoarthritis), such as cold-dampness stasis and the like, treats both symptoms and root causes, and is not easy to relapse.

To correct the tilt of the driver's torso and waist to the left caused by the road surface sloping to the left, we provide a car seat tilt board that is tilted several degrees to the right. [Solution] The driver's seat 5, which slopes to the left along the paved road, is equipped with a seat tilt plate 6 that is thicker on the left side and thinner on the right side. By correcting it to be horizontal, the torso is made vertical, which helps to alleviate physical ailments such as lower back pain, back muscle pain, neck pain, and stiff shoulders.

Described herein are various implementations of systems and methods for determining likelihood of a patient favorably responding to a neuromodulation procedure based on a quantitative or objective score or determination based on a plurality of indicators of pain (e.g., chronic low back pain stemming from one or more vertebral bodies or vertebral endplates of a patient). The systems and methods may involve application of artificial intelligence techniques (e.g., trained algorithms, machine learning or deep learning algorithms, and / or trained neural networks).

Elderly people with back problems are looking for portable folding chairs that can be adjusted in height. [Solution] Two sets of connecting bars with a fulcrum axis in the center and connecting pins with hinge springs mounted on plate-type bearings. Two connecting bars are fixed to the legs of a height-adjustable portable folding chair, and the upper belt-type seat is To provide a portable folding chair with height adjustment, in which two shafted pipes are arranged to support the seat surface.

The invention provides novel small animal waist and back pain detection equipment and method.The detection equipment comprises a supporting frame, a rotating piece rotationally arranged on the supporting frame, a supporting structure fixedly arranged on the rotating piece and used for supporting a small animal, and a detection mechanism fixedly arranged on the supporting structure and used for detecting waist and back pain of the small animal, the small animal can continuously run on the supporting structure, the small animal drives the rotating part through the supporting structure when running so that the rotating part can periodically rotate in one direction, the small animal running device further comprises a measuring assembly, and the measuring assembly is used for measuring the running distance, speed and time of the small animal. Through the arrangement of the rotary supporting structure, the small animal can run spontaneously without manual interference, the measuring assembly can measure the movement distance, speed and time of the small animal, and an experimenter can compare the pain threshold level of a mouse with low back pain according to measured data.

The invention discloses a balance force bonesetting and tendon shifting six-step method which comprises the following steps: (1) observing the whole body: observing whether the standing position, the squatting position, the walking posture, the running posture and the take-off posture of the whole opposite side are normal or not, and observing whether a lumbago person does not coordinate with two legs and does not dare to bend down or not when walking, and whether a knee joint pain person is difficult to walk or not and whether the two knees are deformed or not; (2) local observation: observing whether the opposite side has obvious fracture depression, dislocation, swelling and bruise, the joint part has swelling, the color, the shape and the size, and the muscle and tendon are uniform and smooth, and finding the affected part; by designing the balance force bone-setting tendon-shifting six-step method, the method is used for exercising middle-aged and elderly people with difficulty in leg and foot movement, the exercising effect can be achieved without violent exercise, and the problem that some elderly people are difficult to run, swim and other exercising activities after the legs and the feet become inflexible, and consequently the bodies become worse and worse is effectively solved.

This disclosure relates to compounds of formula I (wherein X and R1-R4, n and m have the meanings set forth herein) and pharmaceutically acceptable salts thereof. Compounds of formula I exhibit GPR183 antagonist activity and are therefore useful in the treatment or prevention of disorders, conditions or diseases for which GPR183 antagonists have been shown to be useful, such as chronic pain, e.g., osteoarthritis, chronic low back pain, neuropathic pain, and immune system disorders, e.g., inflammatory bowel diseases such as colitis and Crohn's disease, multiple sclerosis, rheumatoid arthritis, inflammatory lung diseases, e.g., asthma, and psoriasis. TIFF2026522963000085.tif2570

This invention discloses a system and method for identifying low back pain based on a combined electromyography (EMG) and muscle oxygenation (MOO) array. The system includes: a data generation module for generating EMG and MOO topographic maps based on EMG and MOO information from the lower back; a feature processing module for extracting features from the EMG and MOO topographic maps to obtain EMG and MOO topographic map feature data, wherein the EMG and MOO topographic map feature data are morphological features of areas of high activity; and an analysis and diagnosis module for inputting the EMG and MOO topographic map feature data into a trained neural network model to obtain a low back pain category identification result. This invention improves the objectivity and accuracy of low back pain detection and classification, thereby improving the treatment and rehabilitation effects of low back pain.

This invention discloses the application of a Cav3.2 inhibitor in the preparation of a drug for treating intervertebral disc degeneration. Z944 can block the activation level of Cav3.2 in nucleus pulposus cells, effectively alleviating lipid metabolism disorders and cellular biological behavior disorders induced by abnormal mechanical stress, and ultimately reducing intervertebral disc degeneration. This demonstrates that Z944 is a drug with clinical application potential, which can be used to alleviate the pain and burden of patients with low back pain and improve their quality of life.

The application discloses a kind of massage and whole body vibration training synergistic effect treatment chronic low back pain system, including patient information registration and management module, chronic pain assessment module, treatment effect assessment module, data analysis and feedback module, vibration training control terminal and massage treatment and guidance module;Through guiding patient to complete standardization waist action and record each posture under the pain score, determine main pain area in combination with Pareto analysis method, and utilize the score data in multiple treatments, construct mean and standard deviation model, and then realize the normal distribution fitting of pain change and curative effect determination;Massage and vibration training are linked through system, data intercommunication, realize the standardization of treatment process, intelligent and personalized intervention, effectively improve the rehabilitation efficiency of chronic low back pain patient.The application has the advantages of complete structure, scientific evaluation, precise intervention, etc., and is suitable for the popularization and application in the field of rehabilitation medicine and clinical physical therapy.

Described herein are various implementations of systems and methods for accessing and modulating tissue (for example, systems and methods for accessing and ablating nerves or other tissue within or surrounding a vertebral body to treat chronic lower back pain). Assessment of vertebral endplate degeneration or defects (e.g., pre-Modic changes) to facilitate identification of treatment sites and protocols are also provided in several embodiments. Several embodiments comprise the use of biomarkers to confirm or otherwise assess ablation, pain relief, efficacy of treatment, etc. Some embodiments include robotic elements for, as an example, facilitating robotically controlled access, navigation, imaging, and / or treatment.

The present invention relates to epiregulin antibodies, compositions comprising the same, and methods of making and / or using the antibodies and / or compositions thereof for chronic pain disorders such as chronic osteoarthritis pain, or chronic diabetic peripheral neuropathy pain, or chronic low back pain.

Disclosed herein are compositions and methods for treatment and prevention of low back pain. The compositions include vectors comprising nucleotide sequences encoding one or more CRISPR-Cas system guide RNAs and a RNA-directed nuclease. The methods include modulating expression of one or more genes in a cell using the compositions, introducing a CRISPR-Cas system into a cell comprising one or more vectors comprising the compositions, including site-specific DNA cleavage in a cell, and treating a subject having lower back pain, and lower back pain caused by degenerative disc disease using the compositions disclosed herein.

The present invention relates to a device (1) comprising an object (2) with a biocompatible, sharp, or pointed heating tip, comprising at least one ferromagnetic material, a magnetic field generator (3) adapted to direct the magnetic field of the ferromagnetic material to produce a temperature rise in the heating tip of the object (2), and a temperature control device (4) for the heating tip of the object (2). The present invention also relates to the cosmetic use of the device in the treatment of fine lines, dark circles, and superficial cellulite. Finally, the invention relates to the device for use in the treatment of varicose veins and / or in the treatment of syndromes related to spondylitis and the pain associated with these various conditions, in particular chronic lower back pain or neck pain and their referred pain.

Described herein are various implementations of systems and methods for determining likelihood of a patient favorably responding to a neuromodulation procedure based on a quantitative or objective score or determination based on a plurality of indicators of pain (e.g., chronic low back pain stemming from one or more vertebral bodies or vertebral endplates of a patient). The systems and methods may involve application of artificial intelligence techniques (e.g., trained algorithms, machine learning or deep learning algorithms, and / or trained neural networks).

We provide exercise equipment that allows anyone to easily and enjoyably exercise while watching TV. [Solution] The exercise equipment 5 comprises a base 4, a support column 3 erected on the base, a T-shaped handle 1 housed inside the support column and movable vertically, and a fixing means 2 for fixing the T-shaped handle to the support column at a desired height. When watching TV, hold the exercise equipment with both hands and perform light squats, heel raises, rehabilitation exercises, etc., while standing. Daily exercise supports physical fitness, strengthens the legs and lower back, and has the effect of preventing and alleviating many diseases such as lower back pain, metabolic syndrome, and lifestyle-related diseases. Even when not watching TV, you can do a little exercise anytime, anywhere.

The present invention provides a compound of Formula I:wherein R1 is:or a pharmaceutically acceptable salt thereof, useful for treating pain, including chronic pain, chronic lower back pain, diabetic peripheral neuropathic pain, and osteoarthritis pain.

The invention discloses a chronic nonspecific lumbago prediction model construction method and system, and solves the problem that in the prior art, although research proves that morphological changes of paravertebral muscles are associated with occurrence of cNLBP, an efficient prediction model capable of integrating multi-dimensional data is lacked, the method comprises the steps of S1, obtaining lumbar vertebra MRI image data of a patient; s2, on the basis of an image segmentation technology, segmenting regions of interest of multifidus muscles and erector spinalis muscles on the two sides of 4-5 layers of the waist on the lumbar vertebra MRI image; s3, extracting morphological features and radiomics features of paravertebral muscles based on the region of interest; step S4, the morphological features and the radiomics features are fused, and a multi-modal feature set is constructed; carrying out dimension reduction processing on the multi-modal feature set by adopting a feature screening algorithm so as to screen out a feature subset most relevant to lumbago prediction; and obtaining a chronic nonspecific lumbago prediction model.

The invention discloses a traditional Chinese medicine external application composition prescription and a combined patch for treating lumbago, and the traditional Chinese medicine external application composition prescription comprises the following raw materials by weight: 1-5 parts of garden balsam stem, 0.5-2.5 parts of lycopodium clavatum, 0.5-2.5 parts of Chinese violet, 0.2-2 parts of clematis root, 0.2-2 parts of frankincense, 0.2-2 parts of myrrh, 0.2-2 parts of achyranthes root, 0.2-2 parts of ligusticum wallichii, 0.2-2 parts of cassia twig, 0.2-2 parts of ground beetle, 0.2-2 parts of notopterygium root, and 0.2-2 parts of radix angelicae pubescentis. The traditional Chinese medicine composition is prepared from 0.2-2 parts of radix angelicae sinensis, 0.2-1 part of flos carthami, 0.2-2 parts of radix aconiti preparata, 0.2-2 parts of radix aconiti kusnezoffii preparata, 0.2-2 parts of radix salviae miltiorrhizae, 0.2-2 parts of cortex eucommiae and 0.2-2 parts of radix glycyrrhizae. The medicinal composition provided by the invention is more comprehensive than other similar components for treating lumbago, has the main effects of dispelling wind and eliminating dampness, and promoting blood circulation to remove meridian obstruction, also has the effects of tonifying liver and kidney, and is suitable for arthralgia, soreness and weakness of waist and knees and other symptoms caused by wind-cold damp evil and stagnation of qi and blood stasis. Medicine permeability is improved and accelerated by means of the heating function, blood circulation is promoted, blood stasis is removed, channel warming and cold dispelling are facilitated, meanwhile, traditional Chinese medicine safety is guaranteed to a certain extent through traditional Chinese medicine sterilizing liquid, and allergy is reduced.