The invention provides an M1 line door seal automatic pressing machine. The M1 line door seal automatic pressing machine comprises an installation support, a pressing assembly, a visual induction assembly, an electric control cabinet, a PLC, a centering assembly and a supporting plate. According to the M1 line door seal automatic pressing machine, through the arrangement of the centering assemblyand the visual induction assembly, a visual sensor automatically recognizes a door body model, the PLC controls a centering electric push rod to push centering plates to move, so that the distance between the centering plates is matched with the size of the door body model, the pressing size is adjusted according to needs, the pressing operation of door seals of different sizes is met, and the application range of the pressing machine is widened; and a first compression roller assembly and a second compression roller assembly are arranged, an air cylinder pushes a compression roller plate to move downwards, the door seal is subjected to pressing operation through a compression roller, the PLC controls the downward moving distance of the air cylinder, the pressing force of the compression roller on the door seal is kept consistent, the purpose of controlling the pressing force of the door seal is achieved, and the pressing quality of the door seal is improved.