Simulation system for a control centre of a complex system such as an aircraft (23) made up of one or more control panels (11) with a set of control devices (31, 33, 35, 37, 39) for components of said complex system, comprising a suitable computer system for the simulation of the operation of said control panels (11) by using virtual panels (11′) which include simulated control devices (31′, 33′, 35′, 37′, 39′), implemented in screens (10) which are connected to the components controlled by said control panels (11), or to a simulating device for said connections, so that the signals or variables corresponding to the controlled components are assigned to their corresponding simulated control devices (31′, 33′, 35′, 37′, 39′) in the virtual panels (11′). The invention also refers to a computer-implemented method for the generation of the graphic interface (21) said virtual panels (11′).